BIOMAT Database Logo BIOMAT Database Logo

Insights into ulvan lyase: review of source, biochemical characteristics, structure and catalytic mechanism. 2020

Qian Li, and Fu Hu, and Benwei Zhu, and Fang Ni, and Zhong Yao
College of Food Science and Light Industry, Nanjing Tech University, Nanjing, P.R. China.

Ulvan, a kind of polyanionic heteropolysaccharide consisting of 3-sulfated rhamnose, uronic acids (iduronic acid and glucuronic acid) and xylose, has been widely applied in food and cosmetic industries. In addition, ulvan can be converted into fermentable monosaccharides through the cascade system of carbohydrate-active enzymes. Ulvan lyases can degrade ulvan into ulvan oligosaccharides, which is the first step in the fully degradation of ulvan. Various ulvan lyases have been cloned and characterized from marine bacteria and grouped into five polysaccharide lyase (PL) families, namely: PL24, PL25, PL28, PL37 and PL40 families. The elucidation of the biochemical characterization, action pattern and catalytic mechanism of ulvan lyase would definitely enhance our understanding of the deep utilization of marine bioresource and marine carbon cycling. In this review, we summarized the recent progresses about the source and biochemical characteristics of ulvan lyase. Additionally, the structural characteristics and catalytic mechanisms have been introduced in detail. This comprehensive information should be helpful regarding the application of ulvan lyases.

UI MeSH Term Description Entries
D008958 Models, Molecular Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures. Molecular Models,Model, Molecular,Molecular Model
D009844 Oligosaccharides Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form. Oligosaccharide
D011133 Polysaccharide-Lyases A group of carbon-oxygen lyases. These enzymes catalyze the breakage of a carbon-oxygen bond in polysaccharides leading to an unsaturated product and the elimination of an alcohol. EC 4.2.2. Polysaccharide Lyase,Polysaccharide-Lyase,Lyase, Polysaccharide,Polysaccharide Lyases
D011134 Polysaccharides Long chain polymeric CARBOHYDRATES composed of MONOSACCHARIDES linked by glycosidic bonds. Glycan,Glycans,Polysaccharide
D002384 Catalysis The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction. Catalyses
D017421 Sequence Analysis A multistage process that includes the determination of a sequence (protein, carbohydrate, etc.), its fragmentation and analysis, and the interpretation of the resulting sequence information. Sequence Determination,Analysis, Sequence,Determination, Sequence,Determinations, Sequence,Sequence Determinations,Analyses, Sequence,Sequence Analyses
D020723 Glucuronic Acid A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES. Glucuronate,Glucuronic Acid, 6-(14)C-labeled, (D)-isomer,Glucuronic Acid, Monopotassium Salt,Glucuronic Acid, Monosodium Salt,Monopotassium Glucuronate,Monosodium Glucuronate,Glucuronate, Monopotassium,Glucuronate, Monosodium

Related Publications

Qian Li, and Fu Hu, and Benwei Zhu, and Fang Ni, and Zhong Yao
Insights into acylphosphatase structure and catalytic mechanism.
February 1997, Cellular and molecular life sciences : CMLS,
Qian Li, and Fu Hu, and Benwei Zhu, and Fang Ni, and Zhong Yao
Structure-function analyses of a PL24 family ulvan lyase reveal key features and suggest its catalytic mechanism.
March 2018, The Journal of biological chemistry,
Qian Li, and Fu Hu, and Benwei Zhu, and Fang Ni, and Zhong Yao
New Ulvan-Degrading Polysaccharide Lyase Family: Structure and Catalytic Mechanism Suggests Convergent Evolution of Active Site Architecture.
May 2017, ACS chemical biology,
Qian Li, and Fu Hu, and Benwei Zhu, and Fang Ni, and Zhong Yao
Mechanistic Insights into Substrate Recognition and Catalysis of a New Ulvan Lyase of Polysaccharide Lyase Family 24.
May 2021, Applied and environmental microbiology,
Qian Li, and Fu Hu, and Benwei Zhu, and Fang Ni, and Zhong Yao
Revised domain structure of ulvan lyase and characterization of the first ulvan binding domain.
March 2017, Scientific reports,
Qian Li, and Fu Hu, and Benwei Zhu, and Fang Ni, and Zhong Yao
Novel Molecular Insights into the Catalytic Mechanism of Marine Bacterial Alginate Lyase AlyGC from Polysaccharide Lyase Family 6.
March 2017, The Journal of biological chemistry,
Qian Li, and Fu Hu, and Benwei Zhu, and Fang Ni, and Zhong Yao
Structural studies on M. tuberculosis argininosuccinate lyase and its liganded complex: Insights into catalytic mechanism.
May 2019, IUBMB life,
Qian Li, and Fu Hu, and Benwei Zhu, and Fang Ni, and Zhong Yao
Biochemical characterization of a new ulvan lyase and its applicability in utilization of ulvan and preparation of ulva oligosaccharides.
October 2023, Glycobiology,
Qian Li, and Fu Hu, and Benwei Zhu, and Fang Ni, and Zhong Yao
Insights into the catalytic mechanism of tyrosine phenol-lyase from X-ray structures of quinonoid intermediates.
October 2008, The Journal of biological chemistry,
Qian Li, and Fu Hu, and Benwei Zhu, and Fang Ni, and Zhong Yao
Crystal structure of the nitrosuccinate lyase CreD in complex with fumarate provides insights into the catalytic mechanism for nitrous acid elimination.
April 2018, The FEBS journal,
Copied contents to your clipboard!