-transparent.png){kind=logo}
A histopathological analysis of spontaneous neoplastic and non-neoplastic lesions in aged male RccHan:WIST rats. 2020
Motoki Hojo, and
Yoshimitsu Sakamoto, and
Ai Maeno, and
Kuniaki Tayama, and
Yukie Tada, and
Katsuhiro Yuzawa, and
Hiroshi Ando, and
Yoshikazu Kubo, and
Akemichi Nagasawa, and
Kazuyoshi Tanaka, and
Norio Yano, and
Fujifumi Kaihoko, and
Yuko Hasegawa, and
Toshinari Suzuki, and
Akiko Inomata, and
Takako Moriyasu, and
Katsuhiro Miyajima, and
Dai Nakae
Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health, 3-24-1 Hyakunincho, Shinjuku, Tokyo 169-0073, Japan.
Histopathological information about spontaneous lesions in aged Hannover Wistar rats is limited. In this study, we describe spontaneous lesions found in 39 male RccHan:WIST rats used as a control in a carcinogenicity study. Neoplastic lesions were frequently seen in the endocrine system, such as pituitary adenomas in the pars distalis. This strain exhibited a high incidence of thymoma (10.3%), compared to other strains. We encountered an oligodendroglioma, a pituitary adenoma of the pars intermedia, and a prostate adenocarcinoma, which are comparatively rare in rats. While the variety and incidence of non-neoplastic lesions were similar to those in other strains, several interesting lesions occurred with relatively high incidence, including "harderianization" of the extraorbital lacrimal gland, common bile duct ectasia, and hyperplasia of pulmonary endocrine cells in the lung. Furthermore, comparative analyses demonstrated that the severity of chronic progressive nephropathy and murine progressive cardiomyopathy in RccHan:WIST rats was less than that in F344 rats.
| UI | MeSH Term | Description | Entries |
|---|
Related Publications
Motoki Hojo, and
Yoshimitsu Sakamoto, and
Ai Maeno, and
Kuniaki Tayama, and
Yukie Tada, and
Katsuhiro Yuzawa, and
Hiroshi Ando, and
Yoshikazu Kubo, and
Akemichi Nagasawa, and
Kazuyoshi Tanaka, and
Norio Yano, and
Fujifumi Kaihoko, and
Yuko Hasegawa, and
Toshinari Suzuki, and
Akiko Inomata, and
Takako Moriyasu, and
Katsuhiro Miyajima, and
Dai Nakae
April 2001,
Experimental animals,
Motoki Hojo, and
Yoshimitsu Sakamoto, and
Ai Maeno, and
Kuniaki Tayama, and
Yukie Tada, and
Katsuhiro Yuzawa, and
Hiroshi Ando, and
Yoshikazu Kubo, and
Akemichi Nagasawa, and
Kazuyoshi Tanaka, and
Norio Yano, and
Fujifumi Kaihoko, and
Yuko Hasegawa, and
Toshinari Suzuki, and
Akiko Inomata, and
Takako Moriyasu, and
Katsuhiro Miyajima, and
Dai Nakae
September 1986,
Japanese journal of cancer research : Gann,
Motoki Hojo, and
Yoshimitsu Sakamoto, and
Ai Maeno, and
Kuniaki Tayama, and
Yukie Tada, and
Katsuhiro Yuzawa, and
Hiroshi Ando, and
Yoshikazu Kubo, and
Akemichi Nagasawa, and
Kazuyoshi Tanaka, and
Norio Yano, and
Fujifumi Kaihoko, and
Yuko Hasegawa, and
Toshinari Suzuki, and
Akiko Inomata, and
Takako Moriyasu, and
Katsuhiro Miyajima, and
Dai Nakae
November 1979,
Toxicology and applied pharmacology,
Motoki Hojo, and
Yoshimitsu Sakamoto, and
Ai Maeno, and
Kuniaki Tayama, and
Yukie Tada, and
Katsuhiro Yuzawa, and
Hiroshi Ando, and
Yoshikazu Kubo, and
Akemichi Nagasawa, and
Kazuyoshi Tanaka, and
Norio Yano, and
Fujifumi Kaihoko, and
Yuko Hasegawa, and
Toshinari Suzuki, and
Akiko Inomata, and
Takako Moriyasu, and
Katsuhiro Miyajima, and
Dai Nakae
November 2020,
JNMA; journal of the Nepal Medical Association,
Motoki Hojo, and
Yoshimitsu Sakamoto, and
Ai Maeno, and
Kuniaki Tayama, and
Yukie Tada, and
Katsuhiro Yuzawa, and
Hiroshi Ando, and
Yoshikazu Kubo, and
Akemichi Nagasawa, and
Kazuyoshi Tanaka, and
Norio Yano, and
Fujifumi Kaihoko, and
Yuko Hasegawa, and
Toshinari Suzuki, and
Akiko Inomata, and
Takako Moriyasu, and
Katsuhiro Miyajima, and
Dai Nakae
November 1983,
The Journal of toxicological sciences,
Motoki Hojo, and
Yoshimitsu Sakamoto, and
Ai Maeno, and
Kuniaki Tayama, and
Yukie Tada, and
Katsuhiro Yuzawa, and
Hiroshi Ando, and
Yoshikazu Kubo, and
Akemichi Nagasawa, and
Kazuyoshi Tanaka, and
Norio Yano, and
Fujifumi Kaihoko, and
Yuko Hasegawa, and
Toshinari Suzuki, and
Akiko Inomata, and
Takako Moriyasu, and
Katsuhiro Miyajima, and
Dai Nakae
January 1999,
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie,
Motoki Hojo, and
Yoshimitsu Sakamoto, and
Ai Maeno, and
Kuniaki Tayama, and
Yukie Tada, and
Katsuhiro Yuzawa, and
Hiroshi Ando, and
Yoshikazu Kubo, and
Akemichi Nagasawa, and
Kazuyoshi Tanaka, and
Norio Yano, and
Fujifumi Kaihoko, and
Yuko Hasegawa, and
Toshinari Suzuki, and
Akiko Inomata, and
Takako Moriyasu, and
Katsuhiro Miyajima, and
Dai Nakae
January 2017,
Kathmandu University medical journal (KUMJ),
Motoki Hojo, and
Yoshimitsu Sakamoto, and
Ai Maeno, and
Kuniaki Tayama, and
Yukie Tada, and
Katsuhiro Yuzawa, and
Hiroshi Ando, and
Yoshikazu Kubo, and
Akemichi Nagasawa, and
Kazuyoshi Tanaka, and
Norio Yano, and
Fujifumi Kaihoko, and
Yuko Hasegawa, and
Toshinari Suzuki, and
Akiko Inomata, and
Takako Moriyasu, and
Katsuhiro Miyajima, and
Dai Nakae
August 2014,
Journal of clinical and diagnostic research : JCDR,
Motoki Hojo, and
Yoshimitsu Sakamoto, and
Ai Maeno, and
Kuniaki Tayama, and
Yukie Tada, and
Katsuhiro Yuzawa, and
Hiroshi Ando, and
Yoshikazu Kubo, and
Akemichi Nagasawa, and
Kazuyoshi Tanaka, and
Norio Yano, and
Fujifumi Kaihoko, and
Yuko Hasegawa, and
Toshinari Suzuki, and
Akiko Inomata, and
Takako Moriyasu, and
Katsuhiro Miyajima, and
Dai Nakae
November 2023,
West African journal of medicine,
Motoki Hojo, and
Yoshimitsu Sakamoto, and
Ai Maeno, and
Kuniaki Tayama, and
Yukie Tada, and
Katsuhiro Yuzawa, and
Hiroshi Ando, and
Yoshikazu Kubo, and
Akemichi Nagasawa, and
Kazuyoshi Tanaka, and
Norio Yano, and
Fujifumi Kaihoko, and
Yuko Hasegawa, and
Toshinari Suzuki, and
Akiko Inomata, and
Takako Moriyasu, and
Katsuhiro Miyajima, and
Dai Nakae
January 2012,
International journal of molecular sciences,
