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2,2-Dichlorovinyl-O,O-dimethyl phosphate (DDVP), an extensively used household insecticide, was assayed for its genotoxicity in primary rat tracheal epithelial (RTE) cells. Cytotoxicity of DDVP to RTE cells was dose-dependent, killing about 50% of the cell population at a dose of 80 micrograms/ml. Sister-chromatid exchange (SCE) and chromosomal aberrations induced by this insecticide were positive in RTE cells although the doses needed for significant inductions were much higher than those by a known genotoxic agent, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The level of transformation induced by DDVP in RTE cells was about 1/5 that induced by MNNG at a dose of similar cytotoxicity. The slope of the regression line for induced transformation is 1.27. DDVP probably induces the genotoxic effect in RTE cells by a one-hit mechanism.
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February 1989,
Biochemical pharmacology,
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January 1990,
Environmental and molecular mutagenesis,
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January 1981,
Human genetics,
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September 1959,
A.M.A. archives of industrial health,
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October 1984,
Gigiena i sanitariia,
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July 1979,
Toxicology and applied pharmacology,
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T C Wang
November 1983,
Biulleten' eksperimental'noi biologii i meditsiny,
S Y Lin, and
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T C Wang
January 1988,
Cancer letters,
S Y Lin, and
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August 1999,
Mutation research,
S Y Lin, and
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December 1987,
Zhonghua ya yi xue hui za zhi,
