Biomaterial Database

[Effect of human milk enzymes on carbohydrate metabolism during adaptation of newborn infants in the early neonatal period]. 1988

T K Nabukhotnyĭ, and V E Markevich, and V P Pavliuk, and Iu P Tkachenko

The total activity and isoenzymatic composition of lactic dehydrogenase (LDG), malic dehydrogenase (MDG) and glucose 6-phosphate dehydrogenase (G-6-PDG) were studied in the blood serum and erythrocytes of 56 premature and 18 mature newborns, as well as in colostrum and mature breast milk. The growth of the role of anaerobic glycolysis was observed at the end of the neonatal period in the mature newborns. In highly premature newborns the activity of glycolysis and pentose cycle of glucose oxidation was especially high. Isozymic spectrum of LDG evidences the prevalence of the processes of aerobic glycolysis in the premature which is unfavourable under conditions of hypoxia. The pattern of changes in the MDG spectrum denotes a low activity of reactions of the tricarboxylic acid cycle. Isoenzymatic composition of colostrum and milk is close to that in the newborn's blood. Enzymes of colostrum and milk influence carbohydrate metabolism thus producing favourable effect on the adaptation processes in the newborns.

UI	MeSH Term	Description	Entries
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007770	L-Lactate Dehydrogenase	A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.	Lactate Dehydrogenase,Dehydrogenase, L-Lactate,Dehydrogenase, Lactate,L Lactate Dehydrogenase
D008291	Malate Dehydrogenase	An enzyme that catalyzes the conversion of (S)-malate and NAD+ to oxaloacetate and NADH. EC 1.1.1.37.	Malic Dehydrogenase,NAD-Malate Dehydrogenase,Dehydrogenase, Malate,Dehydrogenase, Malic,Dehydrogenase, NAD-Malate,NAD Malate Dehydrogenase
D008895	Milk, Human	Milk that is produced by HUMAN MAMMARY GLANDS.	Breast Milk,Human Milk,Milk, Breast
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D003126	Colostrum	The thin, yellow, serous fluid secreted by the mammary glands during pregnancy and immediately postpartum before lactation begins. It consists of immunologically active substances, white blood cells, water, protein, fat, and carbohydrates.	Colostrums
D005260	Female		Females
D005954	Glucosephosphate Dehydrogenase		Glucose-6-Phosphate Dehydrogenase,Dehydrogenase, Glucose-6-Phosphate,Dehydrogenase, Glucosephosphate,Glucose 6 Phosphate Dehydrogenase
D006019	Glycolysis	A metabolic process that converts GLUCOSE into two molecules of PYRUVIC ACID through a series of enzymatic reactions. Energy generated by this process is conserved in two molecules of ATP. Glycolysis is the universal catabolic pathway for glucose, free glucose, or glucose derived from complex CARBOHYDRATES, such as GLYCOGEN and STARCH.	Embden-Meyerhof Pathway,Embden-Meyerhof-Parnas Pathway,Embden Meyerhof Parnas Pathway,Embden Meyerhof Pathway,Embden-Meyerhof Pathways,Pathway, Embden-Meyerhof,Pathway, Embden-Meyerhof-Parnas,Pathways, Embden-Meyerhof
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man