BIOMAT Database Logo BIOMAT Database Logo

[Severe Metformin-Associated Lactic Acidosis in a 67-Year-Old Patient]. 2020

Manuel Rattka, and Wolfgang Rottbauer, and Mirjam Keßler

Metformin-associated lactic acidosis (MALA) is a difficult to diagnose and potentially life-threatening disease. We report a rare case of severe MALA treated at our hospital's intensive care unit. Suspected diagnosis of MALA and quick initiation of an adequate therapy containing renal replacement therapy led to successful management of this complicated MALA-case.

UI MeSH Term Description Entries
D007004 Hypoglycemic Agents Substances which lower blood glucose levels. Antidiabetic,Antidiabetic Agent,Antidiabetic Drug,Antidiabetics,Antihyperglycemic,Antihyperglycemic Agent,Hypoglycemic,Hypoglycemic Agent,Hypoglycemic Drug,Antidiabetic Agents,Antidiabetic Drugs,Antihyperglycemic Agents,Antihyperglycemics,Hypoglycemic Drugs,Hypoglycemic Effect,Hypoglycemic Effects,Hypoglycemics,Agent, Antidiabetic,Agent, Antihyperglycemic,Agent, Hypoglycemic,Agents, Antidiabetic,Agents, Antihyperglycemic,Agents, Hypoglycemic,Drug, Antidiabetic,Drug, Hypoglycemic,Drugs, Antidiabetic,Drugs, Hypoglycemic,Effect, Hypoglycemic,Effects, Hypoglycemic
D007362 Intensive Care Units Hospital units providing continuous surveillance and care to acutely ill patients. ICU Intensive Care Units,Intensive Care Unit,Unit, Intensive Care
D008687 Metformin A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289) Dimethylguanylguanidine,Dimethylbiguanidine,Glucophage,Metformin HCl,Metformin Hydrochloride,HCl, Metformin,Hydrochloride, Metformin
D003924 Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY. Diabetes Mellitus, Adult-Onset,Diabetes Mellitus, Ketosis-Resistant,Diabetes Mellitus, Maturity-Onset,Diabetes Mellitus, Non-Insulin-Dependent,Diabetes Mellitus, Slow-Onset,Diabetes Mellitus, Stable,MODY,Maturity-Onset Diabetes Mellitus,NIDDM,Diabetes Mellitus, Non Insulin Dependent,Diabetes Mellitus, Noninsulin Dependent,Diabetes Mellitus, Noninsulin-Dependent,Diabetes Mellitus, Type II,Maturity-Onset Diabetes,Noninsulin-Dependent Diabetes Mellitus,Type 2 Diabetes,Type 2 Diabetes Mellitus,Adult-Onset Diabetes Mellitus,Diabetes Mellitus, Adult Onset,Diabetes Mellitus, Ketosis Resistant,Diabetes Mellitus, Maturity Onset,Diabetes Mellitus, Slow Onset,Diabetes, Maturity-Onset,Diabetes, Type 2,Ketosis-Resistant Diabetes Mellitus,Maturity Onset Diabetes,Maturity Onset Diabetes Mellitus,Non-Insulin-Dependent Diabetes Mellitus,Noninsulin Dependent Diabetes Mellitus,Slow-Onset Diabetes Mellitus,Stable Diabetes Mellitus
D006761 Hospitals Institutions with an organized medical staff which provide medical care to patients. Hospital
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000140 Acidosis, Lactic Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE. Lactic Acidosis
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D017582 Renal Replacement Therapy Procedures which temporarily or permanently remedy insufficient cleansing of body fluids by the kidneys. Kidney Replacement Therapy,Replacement Therapy, Kidney,Replacement Therapy, Renal,Therapy, Kidney Replacement,Therapy, Renal Replacement,Kidney Replacement Therapies,Renal Replacement Therapies,Replacement Therapies, Kidney,Replacement Therapies, Renal,Therapies, Kidney Replacement,Therapies, Renal Replacement

Related Publications

Manuel Rattka, and Wolfgang Rottbauer, and Mirjam Keßler
Transient vision loss in a patient with severe metformin-associated lactic acidosis.
August 2012, QJM : monthly journal of the Association of Physicians,
Manuel Rattka, and Wolfgang Rottbauer, and Mirjam Keßler
Transient Blindness in a Patient with Severe Metformin-Associated Lactic Acidosis (MALA).
June 2019, Electrolyte & blood pressure : E & BP,
Manuel Rattka, and Wolfgang Rottbauer, and Mirjam Keßler
Metformin-associated lactic acidosis in a pregnant patient.
January 2008, Gynecologic and obstetric investigation,
Manuel Rattka, and Wolfgang Rottbauer, and Mirjam Keßler
Metformin-associated lactic acidosis in a burn patient.
January 2007, Journal of burn care & research : official publication of the American Burn Association,
Manuel Rattka, and Wolfgang Rottbauer, and Mirjam Keßler
[Severe lactic acidosis associated to metformin intoxication].
January 2007, Nutricion hospitalaria,
Manuel Rattka, and Wolfgang Rottbauer, and Mirjam Keßler
Metformin-associated lactic acidosis in a low risk patient.
January 2001, The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique,
Manuel Rattka, and Wolfgang Rottbauer, and Mirjam Keßler
Metformin-associated lactic acidosis in a peritoneal dialysis patient.
March 2015, Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia,
Manuel Rattka, and Wolfgang Rottbauer, and Mirjam Keßler
Unexpected survival from severe metformin-associated lactic acidosis.
October 2003, The Netherlands journal of medicine,
Manuel Rattka, and Wolfgang Rottbauer, and Mirjam Keßler
[Metformin-related lactic acidosis in an 85-year-old woman].
July 2007, Nederlands tijdschrift voor geneeskunde,
Manuel Rattka, and Wolfgang Rottbauer, and Mirjam Keßler
[Metformin-related lactic acidosis in an 85-year-old woman].
July 2007, Nederlands tijdschrift voor geneeskunde,
Copied contents to your clipboard!