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The lactulose hydrogen breath-test provides a non-invasive measure of mouth to caecum transit-time. Its use, particularly in children has not been thoroughly investigated. We have studied the effects on transit time of altering the lactulose concentration of the test solution, and of administering it in a liquid nutrient preparation. Concentration markedly affected transit-time; studies with an isotonic solution may be least affected by delayed gastric emptying, and so may reflect small bowel transit-time. Day-to-day variation was large, and was not reduced by altering lactulose concentration, or by using the liquid nutrient based test solution. There was no correlation between age and transit-time.
M S Murphy, and
R Nelson, and
E J Eastham
December 1999,
Journal of gastroenterology,
M S Murphy, and
R Nelson, and
E J Eastham
April 1988,
Lancet (London, England),
M S Murphy, and
R Nelson, and
E J Eastham
August 2015,
Journal of clinical gastroenterology,
M S Murphy, and
R Nelson, and
E J Eastham
November 1977,
The American journal of gastroenterology,
M S Murphy, and
R Nelson, and
E J Eastham
July 1991,
Journal of pediatric gastroenterology and nutrition,
M S Murphy, and
R Nelson, and
E J Eastham
July 1946,
Bulletin de l'Academie veterinaire de France,
M S Murphy, and
R Nelson, and
E J Eastham
October 1983,
British medical journal (Clinical research ed.),
M S Murphy, and
R Nelson, and
E J Eastham
January 1985,
Cancer chemotherapy and pharmacology,
M S Murphy, and
R Nelson, and
E J Eastham
January 1997,
Biomedizinische Technik. Biomedical engineering,
M S Murphy, and
R Nelson, and
E J Eastham
February 1990,
The American journal of gastroenterology,
