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Small size nanoparticles-Co3O4 based lateral flow immunoassay biosensor for highly sensitive and rapid detection of furazolidone. 2020

Lihong Su, and Lulu Wang, and Xiaolin Yao, and Xuechi Yin, and Han Zhang, and Man Zhao, and Sijie Liu, and Zonghan Wang, and Jianlong Wang, and Daohong Zhang
College of Food Science and Engineering, Northwest A&F University, Yangling, 712100, Shaanxi, China.

Lateral flow immunoassay (LFIA) biosensor is a paper-based tool and widely utilized in various fields. Here, we developed a novel LFIA biosensor by introducing Co3O4 nanoparticles (NPs) as signal labels for highly sensitive detection of 3-amino-2-oxazolidinone (AOZ), a metabolite of furazolidone. The characteristic brown color of Co3O4 NPs enabled AOZ to be visually detected by the LFIA. Significantly, the size of Co3O4 NPs is relatively small compared with most of other signal labels, which could remarkably reduce steric hindrance, increase immunoreaction probability and shorten the analysis time. Under optimal conditions, the novel Co3O4 NPs-LFIA could possess high sensitivity for the detection of AOZ with a detection limit of 0.4 ng mL-1 by naked eyes, which was at least 3-fold improved than that of the conventional gold nanoparticles (GNPs) based LFIA. Moreover, the detection could be achieved within 6 min and without cross-reactions with other analogue small molecules. Taking merits of convenience, rapid and sensitivity, the proposed Co3O4 NPs-LFIA may be readily adapted for the detection of other small molecules.

UI MeSH Term Description Entries
D007118 Immunoassay A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance. Immunochromatographic Assay,Assay, Immunochromatographic,Assays, Immunochromatographic,Immunoassays,Immunochromatographic Assays
D010087 Oxides Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides. Oxide
D003035 Cobalt A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis. Cobalt-59,Cobalt 59
D005506 Food Contamination The presence in food of harmful, unpalatable, or otherwise objectionable foreign substances, e.g. chemicals, microorganisms or diluents, before, during, or after processing or storage. Food Adulteration,Adulteration, Food,Adulterations, Food,Contamination, Food,Contaminations, Food,Food Adulterations,Food Contaminations
D005664 Furazolidone A nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone acts by gradual inhibition of monoamine oxidase. (From Martindale, The Extra Pharmacopoeia, 30th ed, p514) Nifurazolidone,Furazol,Furazolidine,Furoxone
D006046 Gold A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015374 Biosensing Techniques Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal. Bioprobes,Biosensors,Electrodes, Enzyme,Biosensing Technics,Bioprobe,Biosensing Technic,Biosensing Technique,Biosensor,Electrode, Enzyme,Enzyme Electrode,Enzyme Electrodes,Technic, Biosensing,Technics, Biosensing,Technique, Biosensing,Techniques, Biosensing
D053768 Metal Nanoparticles Nanoparticles produced from metals whose uses include biosensors, optics, and catalysts. In biomedical applications the particles frequently involve the noble metals, especially gold and silver. Metal Nanocrystals,Metallic Nanocrystals,Metallic Nanoparticles,Metal Nanocrystal,Metal Nanoparticle,Metallic Nanocrystal,Metallic Nanoparticle,Nanocrystal, Metal,Nanocrystal, Metallic,Nanocrystals, Metal,Nanocrystals, Metallic,Nanoparticle, Metal,Nanoparticle, Metallic,Nanoparticles, Metal,Nanoparticles, Metallic
D057230 Limit of Detection Concentration or quantity that is derived from the smallest measure that can be detected with reasonable certainty for a given analytical procedure. Limits of Detection,Detection Limit,Detection Limits

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