-transparent.png){kind=logo}
Although evidence for a role for prostaglandins in parturition is abundant, less is known about how prostaglandin levels are regulated at term. Conditions occurring peripartum in the uteroplacental unit can result in reactive oxygen production. We investigated the effect of one reactive oxygen product, hydrogen peroxide, on in vitro activity of uterine segments from the 18-day-pregnant rat. H2O2 (0.3 mmol/L) was found to elicit rhythmic contractions and increase prostaglandins F2 alpha and E2 release by uterine tissue. Indomethacin blocked both of these effects. We conclude that H2O2 stimulates uterine contractions through a prostaglandin release mechanism. A speculative hypothesis of peripartum regulation of prostaglandin production by reactive oxygen is discussed.
P H Cherouny, and
R B Ghodgaonkar, and
J R Niebyl, and
N H Dubin
May 1972,
British journal of pharmacology,
P H Cherouny, and
R B Ghodgaonkar, and
J R Niebyl, and
N H Dubin
June 1984,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
P H Cherouny, and
R B Ghodgaonkar, and
J R Niebyl, and
N H Dubin
January 2001,
American journal of obstetrics and gynecology,
P H Cherouny, and
R B Ghodgaonkar, and
J R Niebyl, and
N H Dubin
March 1982,
Biology of reproduction,
P H Cherouny, and
R B Ghodgaonkar, and
J R Niebyl, and
N H Dubin
January 1985,
The Indian journal of medical research,
P H Cherouny, and
R B Ghodgaonkar, and
J R Niebyl, and
N H Dubin
January 1997,
Pulmonary pharmacology & therapeutics,
P H Cherouny, and
R B Ghodgaonkar, and
J R Niebyl, and
N H Dubin
September 1997,
Prostaglandins, leukotrienes, and essential fatty acids,
P H Cherouny, and
R B Ghodgaonkar, and
J R Niebyl, and
N H Dubin
August 1973,
British journal of pharmacology,
P H Cherouny, and
R B Ghodgaonkar, and
J R Niebyl, and
N H Dubin
March 1983,
The Indian journal of medical research,
P H Cherouny, and
R B Ghodgaonkar, and
J R Niebyl, and
N H Dubin
November 1977,
European journal of pharmacology,
