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TLC, GLC and GC-MS methods were applied for studying the fatty acid composition of rat cerebellum phospholipids. 75 male Wistar rats had a diet without fat for 6 weeks and then a diet with linseed oil, fish oil in combination with lard and mixture of sunflower oil with lard (control group) for 3 months; PUFA omega 6/omega 3 rations were 0.27; 0.5 and 45.0. PUFA omega 3 in all fractions were represented mainly by 22:6 omega 3 (0.2-12.0%) acid and its share depends on the total PUFA omega 3 amount in the diet. The absence of 18:3, 20:5 and 22:5 omega 3 in cerebellum lipids, fed in great amount with test diets, suggested that these acids are rapidly desaturated and elongated to 22:6 omega 3 at the blood-brain barrier. Established competitive inhibition of desaturases responsible for the synthesis of tissues PUFA omega 6 and omega 3 proves the expressed regulatory effect of alimentary factor on brain lipids.
F A Medvedev, and
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M M Levachev
December 1982,
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F A Medvedev, and
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M M Levachev
May 1997,
Bioscience, biotechnology, and biochemistry,
F A Medvedev, and
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Best practice & research. Clinical gastroenterology,
F A Medvedev, and
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November 2009,
Postgraduate medicine,
F A Medvedev, and
S N Kulakova, and
M M Levachev
August 1997,
The British journal of nutrition,
F A Medvedev, and
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M M Levachev
April 1995,
Bioscience, biotechnology, and biochemistry,
F A Medvedev, and
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M M Levachev
July 2011,
Experimental dermatology,
F A Medvedev, and
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M M Levachev
January 2009,
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica,
F A Medvedev, and
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January 2009,
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica,
F A Medvedev, and
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Bibliotheca nutritio et dieta,
