-transparent.png){kind=logo}
Four elderly patients developed nephrotic syndrome while receiving sulindac. Sulindac treatment had commenced 4-12 months prior to presentation with the nephrotic syndrome. Two patients also developed oliguric renal failure. Renal biopsy in one showed minimal change nephropathy and in three cases membranous nephropathy. Interstitial nephritis was present on renal biopsy in all cases. The nephrotic syndrome and renal failure resolved in all cases after withdrawal of sulindac. Two patients received steroid therapy and improvement in renal function and disappearance of proteinuria seemed to be temporarily related to steroid therapy in both cases. Despite the fact that sulindac is less likely to cause renal failure due to inhibition of renal prostaglandin secretion this report shows that sulindac treatment can be associated with renal failure and the nephrotic syndrome.
P J Champion de Crespigny, and
G J Becker, and
B U Ihle, and
N M Walter, and
C A Wright, and
P Kincaid-Smith
February 1981,
The New England journal of medicine,
P J Champion de Crespigny, and
G J Becker, and
B U Ihle, and
N M Walter, and
C A Wright, and
P Kincaid-Smith
February 2010,
Pediatrics international : official journal of the Japan Pediatric Society,
P J Champion de Crespigny, and
G J Becker, and
B U Ihle, and
N M Walter, and
C A Wright, and
P Kincaid-Smith
October 2003,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
P J Champion de Crespigny, and
G J Becker, and
B U Ihle, and
N M Walter, and
C A Wright, and
P Kincaid-Smith
October 1992,
Revista clinica espanola,
P J Champion de Crespigny, and
G J Becker, and
B U Ihle, and
N M Walter, and
C A Wright, and
P Kincaid-Smith
July 1982,
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis,
P J Champion de Crespigny, and
G J Becker, and
B U Ihle, and
N M Walter, and
C A Wright, and
P Kincaid-Smith
August 1967,
Virginia medical monthly,
P J Champion de Crespigny, and
G J Becker, and
B U Ihle, and
N M Walter, and
C A Wright, and
P Kincaid-Smith
September 1956,
British medical journal,
P J Champion de Crespigny, and
G J Becker, and
B U Ihle, and
N M Walter, and
C A Wright, and
P Kincaid-Smith
July 1983,
JAMA,
P J Champion de Crespigny, and
G J Becker, and
B U Ihle, and
N M Walter, and
C A Wright, and
P Kincaid-Smith
January 1989,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
P J Champion de Crespigny, and
G J Becker, and
B U Ihle, and
N M Walter, and
C A Wright, and
P Kincaid-Smith
February 1995,
The American journal of gastroenterology,
