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The concentrations of azlocillin and mezlocillin in human prostatic tissue obtained by transurethral resection or enucleation were measured after two 2.0-gram doses of either drug. The average plasma concentration of azlocillin and mezlocillin at time of tissue sampling was 64.9 and 36.3 micrograms/ml, respectively, and tissue concentration at the time of sampling was 22.9 micrograms/g for azlocillin and 9.4 micrograms/g for mezlocillin. The plasma/tissue concentration ratio for mezlocillin was 0.25 and for azlocillin 0.35. Concentrations of mezlocillin in tissue obtained by transurethral resection were similar to those obtained by enucleation. Azlocillin and mezlocillin in appropriate doses achieve a concentration in human prostatic tissue above the inhibitory concentration for common bacterial pathogens.
R P Smith, and
H J Wilbur, and
C Bassey, and
A L Baltch
March 1988,
Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology,
R P Smith, and
H J Wilbur, and
C Bassey, and
A L Baltch
May 1983,
The Journal of antimicrobial chemotherapy,
R P Smith, and
H J Wilbur, and
C Bassey, and
A L Baltch
January 1984,
Reviews of infectious diseases,
R P Smith, and
H J Wilbur, and
C Bassey, and
A L Baltch
May 1983,
The Journal of antimicrobial chemotherapy,
R P Smith, and
H J Wilbur, and
C Bassey, and
A L Baltch
June 1978,
Antimicrobial agents and chemotherapy,
R P Smith, and
H J Wilbur, and
C Bassey, and
A L Baltch
August 1984,
Zeitschrift fur die gesamte Hygiene und ihre Grenzgebiete,
R P Smith, and
H J Wilbur, and
C Bassey, and
A L Baltch
March 1981,
Orvosi hetilap,
R P Smith, and
H J Wilbur, and
C Bassey, and
A L Baltch
October 1986,
Hinyokika kiyo. Acta urologica Japonica,
R P Smith, and
H J Wilbur, and
C Bassey, and
A L Baltch
November 1982,
Annals of internal medicine,
R P Smith, and
H J Wilbur, and
C Bassey, and
A L Baltch
January 1979,
Medizinische Klinik,
