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The primary tumour properties are studied for their effect on the recurrent tumour growth and metastatic spreading after chemotherapy. Serial transplantation of the B16 melanoma to (CBA X C57Bl/6)F1 mice induced gradual changes in tumour malignancy. With an increase of the generation number the metastatic activity of hybrid mice rises and chemotherapeutic sensitivity lowers. The thirty-first and the fifty-fourth tumour generations after the chemotherapy metastasize earlier and the number of metastases increases more rapidly as compared with the recurrence of the primary tumour. The metastatic potential of recurrent tumours increases with the number of generations in hybrid mice.
E G Kiseleva, and
L M Volkova, and
T N Iakushchenko, and
N P Konovalova
January 1988,
Eksperimental'naia onkologiia,
E G Kiseleva, and
L M Volkova, and
T N Iakushchenko, and
N P Konovalova
April 1996,
Doklady Akademii nauk,
E G Kiseleva, and
L M Volkova, and
T N Iakushchenko, and
N P Konovalova
August 1978,
Biulleten' eksperimental'noi biologii i meditsiny,
E G Kiseleva, and
L M Volkova, and
T N Iakushchenko, and
N P Konovalova
February 1970,
Journal of the National Cancer Institute,
E G Kiseleva, and
L M Volkova, and
T N Iakushchenko, and
N P Konovalova
September 1977,
Transplantation,
E G Kiseleva, and
L M Volkova, and
T N Iakushchenko, and
N P Konovalova
January 1994,
Archives of medical research,
E G Kiseleva, and
L M Volkova, and
T N Iakushchenko, and
N P Konovalova
January 1982,
Archives of dermatological research,
E G Kiseleva, and
L M Volkova, and
T N Iakushchenko, and
N P Konovalova
August 1996,
Journal of anatomy,
E G Kiseleva, and
L M Volkova, and
T N Iakushchenko, and
N P Konovalova
November 1987,
Journal of the National Cancer Institute,
E G Kiseleva, and
L M Volkova, and
T N Iakushchenko, and
N P Konovalova
December 1983,
Journal of the National Cancer Institute,
