BIOMAT Database Logo BIOMAT Database Logo

[The measurement of plasma-free testosterone in normal menstrual females, pregnant females, post menopausal females and vulvar dystrophy]. 1988

A Yamaguchi, and T Ichimura, and T Yamabe
Department of Obstetrics and Gynecology, School of Medicine, Nagasaki University, Japan.

It is considered that plasma-free testosterone is a bioactive androgen in blood and is more reflective in androgenicity than plasma total testosterone. We measured plasma-free testosterone by dialyzable method in normal menstrual females, pregnant females, post menopausal females and vulvar dystrophy. The values of plasma total testosterone (T), fractional free testosterone (%FT) and plasma-free testosterone (free T) were 0.61 +/- 0.27 (mean +/- SD)ng/ml, 1.19 +/- 0.34% and 0.61 +/- 0.20 ng/kl in the follicular phase of normal menstrual females (n = 25), and 0.57 +/- 0.23 ng/ml, 1.29 +/- 0.46% and 0.56 +/- 0.35 ng/dl in the luteal phase of normal menstrual females (n = 24), respectively. The values in both phases showed no differences from each other. In post menopausal females (n = 18), the concentration of T (0.36 +/- 0.27 ng/ml) and free T (0.52 +/- 0.12 ng/dl) was significantly lower (T: P less than 0.01, free T: P less than 0.05) than that in normal menstrual females. However, %FT in post menopausal females (1.37 +/- 0.12%) was not different as compared with that in normal menstrual females. In pregnant females (n = 2) of second and third trimester, T (0.53 +/- 0.07 ng/ml) was not different as compared with that in normal menstrual females, but %FT (0.67 +/- 0.45%) and free T (0.33 +/- 0.23 ng/dl) were significantly lower (P less than 0.05) than in normal menstrual females. In vulvar dystrophy, lichen sclerosus (n = 19) and hyperplastic dystrophy without atypia (n = 12) were measured.(ABSTRACT TRUNCATED AT 250 WORDS)

UI MeSH Term Description Entries
D008593 Menopause The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age. Change of Life, Female
D008597 Menstrual Cycle The period from onset of one menstrual bleeding (MENSTRUATION) to the next in an ovulating woman or female primate. The menstrual cycle is regulated by endocrine interactions of the HYPOTHALAMUS; the PITUITARY GLAND; the ovaries; and the genital tract. The menstrual cycle is divided by OVULATION into two phases. Based on the endocrine status of the OVARY, there is a FOLLICULAR PHASE and a LUTEAL PHASE. Based on the response in the ENDOMETRIUM, the menstrual cycle is divided into a proliferative and a secretory phase. Endometrial Cycle,Ovarian Cycle,Cycle, Endometrial,Cycle, Menstrual,Cycle, Ovarian,Cycles, Endometrial,Cycles, Menstrual,Cycles, Ovarian,Endometrial Cycles,Menstrual Cycles,Ovarian Cycles
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D013739 Testosterone A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL. 17-beta-Hydroxy-4-Androsten-3-one,17-beta-Hydroxy-8 alpha-4-Androsten-3-one,8-Isotestosterone,AndroGel,Androderm,Andropatch,Androtop,Histerone,Sterotate,Sustanon,Testim,Testoderm,Testolin,Testopel,Testosterone Sulfate,17 beta Hydroxy 4 Androsten 3 one,17 beta Hydroxy 8 alpha 4 Androsten 3 one,8 Isotestosterone
D014845 Vulvar Diseases Pathological processes of the VULVA. Disease, Vulvar,Diseases, Vulvar,Vulvar Disease

Related Publications

A Yamaguchi, and T Ichimura, and T Yamabe
Free plasma testosterone levels during the normal menstrual cycle.
October 1985, Journal of endocrinological investigation,
A Yamaguchi, and T Ichimura, and T Yamabe
[Plasma estradiol and plasma testosterone values during the normal menstrual cycle].
January 1977, Akusherstvo i ginekologiia,
A Yamaguchi, and T Ichimura, and T Yamabe
Errors in the measurement of plasma free testosterone.
June 1997, The Journal of clinical endocrinology and metabolism,
A Yamaguchi, and T Ichimura, and T Yamabe
[Free testosterone and epitestosterone and glucosiduronates in the urine of females. II. Behavior in the menstrual cycle].
December 1966, Folia endocrinologica,
A Yamaguchi, and T Ichimura, and T Yamabe
PLASMA SODIUM AND THE EEG DURING THE MENSTRUAL CYCLE OF NORMAL HUMAN FEMALES.
November 1964, Electroencephalography and clinical neurophysiology,
A Yamaguchi, and T Ichimura, and T Yamabe
[VULVAR DYSTROPHY IN THE POST-MENOPAUSE PERIOD].
January 1965, La Presse thermale et climatique,
A Yamaguchi, and T Ichimura, and T Yamabe
Free testosterone levels during the menstrual cycle in obese versus normal women.
March 1989, Fertility and sterility,
A Yamaguchi, and T Ichimura, and T Yamabe
Bioequivalence of exemestane in post-menopausal females.
January 2010, Arzneimittel-Forschung,
A Yamaguchi, and T Ichimura, and T Yamabe
[Para-and post-menopausal uterine dystrophy].
January 1968, Journal de radiologie, d'electrologie, et de medecine nucleaire,
A Yamaguchi, and T Ichimura, and T Yamabe
Steroid hormones and aging: free testosterone, testosterone and androstenedione in normal females aged 20-87 years.
May 1980, Human biology,
Copied contents to your clipboard!