Control of cell shape during epithelial morphogenesis: recent advances. 2020

Ghislain Gillard, and Katja Röper
MRC-Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. Electronic address: ggillard@mrc-lmb.cam.ac.uk.

Morphogenesis is an essential process by which a given tissue, organ or organism acquires its final shape. A select number of mechanisms are used in order to drive epithelial morphogenesis, including cell shape changes as well as cell death or cell division. A cell's shape results from the combination of intrinsic properties of the actomyosin and microtubule (MTs) cytoskeletons, and extrinsic properties due to physical interactions with the neighbouring environment. While we now have a good understanding of the genetic pathways and some of the signalling pathways controlling cell shape changes, the mechanical properties of cells and their role in morphogenesis remain largely unexplored. Recent improvements in microscopy techniques and the development of modelling and quantitative methods have enabled a better understanding of the bio-mechanical events controlling cell shape during morphogenesis. This review aims to highlight recent findings elegantly unravelling and quantifying the contribution of mechanical forces during morphogenesis.

UI MeSH Term Description Entries
D008841 Actin Cytoskeleton Fibers composed of MICROFILAMENT PROTEINS, which are predominately ACTIN. They are the smallest of the cytoskeletal filaments. Actin Filaments,Microfilaments,Actin Microfilaments,Actin Cytoskeletons,Actin Filament,Actin Microfilament,Cytoskeleton, Actin,Cytoskeletons, Actin,Filament, Actin,Filaments, Actin,Microfilament,Microfilament, Actin,Microfilaments, Actin
D009024 Morphogenesis The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.
D004847 Epithelial Cells Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells. Adenomatous Epithelial Cells,Columnar Glandular Epithelial Cells,Cuboidal Glandular Epithelial Cells,Glandular Epithelial Cells,Squamous Cells,Squamous Epithelial Cells,Transitional Epithelial Cells,Adenomatous Epithelial Cell,Cell, Adenomatous Epithelial,Cell, Epithelial,Cell, Glandular Epithelial,Cell, Squamous,Cell, Squamous Epithelial,Cell, Transitional Epithelial,Cells, Adenomatous Epithelial,Cells, Epithelial,Cells, Glandular Epithelial,Cells, Squamous,Cells, Squamous Epithelial,Cells, Transitional Epithelial,Epithelial Cell,Epithelial Cell, Adenomatous,Epithelial Cell, Glandular,Epithelial Cell, Squamous,Epithelial Cell, Transitional,Epithelial Cells, Adenomatous,Epithelial Cells, Glandular,Epithelial Cells, Squamous,Epithelial Cells, Transitional,Glandular Epithelial Cell,Squamous Cell,Squamous Epithelial Cell,Transitional Epithelial Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D048430 Cell Shape The quality of surface form or outline of CELLS. Cell Shapes,Shape, Cell,Shapes, Cell

Related Publications

Ghislain Gillard, and Katja Röper
August 1994, Current biology : CB,
Ghislain Gillard, and Katja Röper
March 2015, Developmental cell,
Ghislain Gillard, and Katja Röper
September 2006, Developmental dynamics : an official publication of the American Association of Anatomists,
Ghislain Gillard, and Katja Röper
March 1987, Pediatric research,
Ghislain Gillard, and Katja Röper
September 2018, The Journal of cell biology,
Ghislain Gillard, and Katja Röper
April 2008, Current opinion in cell biology,
Ghislain Gillard, and Katja Röper
October 2000, Current opinion in genetics & development,
Ghislain Gillard, and Katja Röper
July 2008, Development (Cambridge, England),
Ghislain Gillard, and Katja Röper
January 2021, Frontiers in cell and developmental biology,
Copied contents to your clipboard!