BIOMAT Database Logo BIOMAT Database Logo

Thermal distribution, physiological effects and toxicities of extracorporeally induced whole-body hyperthermia in a pig model. 2020

Gerben Lassche, and Tim Frenzel, and Marcel H Mignot, and Marianne A Jonker, and Johannes G van der Hoeven, and Carla M L van Herpen, and Gert Jan Scheffer
Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.

Extracorporeally induced whole-body hyperthermia (eWBH) might be a beneficial treatment in cancer patients. Objectives of this pig study were to assess thermal distribution, (patho-)physiological effects, and safety of eWBH with a new WBH device. Fourteen healthy adult pigs were anesthetized, mechanically ventilated, and cannulated; 12 were included in the analysis. Blood was heated in 11 pigs (one pig served as control) using a WBH device (Vithèr Hyperthermia B.V.) containing two separate fluidic circuits and a heat exchanger. Temperature was monitored on nine different sites, including the brain. Core temperature (average of 4 deep probes) was elevated to 42°C for 2 hr. Elevation of core body temperature to 42°C took on average (± standard deviation) 38 ± 8 min. Initially observed temperature spikes diminished after lowering maximal blood temperature to 45°C. Hereafter, brain temperature spikes never exceeded 42.5°C, mean brain temperature was at highest 41.9°C during maintenance. WBH resulted in increased heart rates and decreased mean arterial pressures. The vast amounts of fluids required to counter hypotension tended to be smaller after corticosteroid administration. Hemodialysis was started in three animals (potassium increase prevention in two and hyperkalemia treatment in one). Severe rhabdomyolysis was observed in all pigs (including the control). All animals survived the procedure until planned euthanasia 1, 6, or 24 hr post procedure. Fast induction of eWBH with homogenous thermal distribution is feasible in pigs using the Vithèr WBH device. Severe hemodynamic disturbances, rhabdomyolysis, and hyperkalemia were observed.

UI MeSH Term Description Entries
D006979 Hyperthermia, Induced Abnormally high temperature intentionally induced in living things regionally or whole body. It is most often induced by radiation (heat waves, infra-red), ultrasound, or drugs. Fever Therapy,Hyperthermia, Local,Hyperthermia, Therapeutic,Thermotherapy,Induced Hyperthermia,Therapeutic Hyperthermia,Therapy, Fever,Local Hyperthermia
D007022 Hypotension Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients. Blood Pressure, Low,Hypotension, Vascular,Low Blood Pressure,Vascular Hypotension
D008297 Male Males
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D001831 Body Temperature The measure of the level of heat of a human or animal. Organ Temperature,Body Temperatures,Organ Temperatures,Temperature, Body,Temperature, Organ,Temperatures, Body,Temperatures, Organ
D006339 Heart Rate The number of times the HEART VENTRICLES contract per unit of time, usually per minute. Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006435 Renal Dialysis Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION. Dialysis, Extracorporeal,Dialysis, Renal,Extracorporeal Dialysis,Hemodialysis,Dialyses, Extracorporeal,Dialyses, Renal,Extracorporeal Dialyses,Hemodialyses,Renal Dialyses
D006947 Hyperkalemia Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed) Hyperpotassemia,Hyperkalemias,Hyperpotassemias
D000305 Adrenal Cortex Hormones HORMONES produced by the ADRENAL CORTEX, including both steroid and peptide hormones. The major hormones produced are HYDROCORTISONE and ALDOSTERONE. Adrenal Cortex Hormone,Corticoid,Corticoids,Corticosteroid,Corticosteroids,Cortex Hormone, Adrenal,Hormone, Adrenal Cortex,Hormones, Adrenal Cortex
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

Gerben Lassche, and Tim Frenzel, and Marcel H Mignot, and Marianne A Jonker, and Johannes G van der Hoeven, and Carla M L van Herpen, and Gert Jan Scheffer
[Extracorporeally induced whole-body hyperthermia in conventionally incurable malignant tumor patients].
March 1983, Deutsche medizinische Wochenschrift (1946),
Gerben Lassche, and Tim Frenzel, and Marcel H Mignot, and Marianne A Jonker, and Johannes G van der Hoeven, and Carla M L van Herpen, and Gert Jan Scheffer
A whole body thermal model of man during hyperthermia.
May 1987, IEEE transactions on bio-medical engineering,
Gerben Lassche, and Tim Frenzel, and Marcel H Mignot, and Marianne A Jonker, and Johannes G van der Hoeven, and Carla M L van Herpen, and Gert Jan Scheffer
Extracorporeally induced total-body hyperthermia for disseminated cancer.
January 1990, Advances in experimental medicine and biology,
Gerben Lassche, and Tim Frenzel, and Marcel H Mignot, and Marianne A Jonker, and Johannes G van der Hoeven, and Carla M L van Herpen, and Gert Jan Scheffer
A comparison of thermal enhancement of cis-diamminedichloroplatinum (II) induced renal and intestinal toxicities by whole body hyperthermia in the rat.
June 1989, International journal of radiation oncology, biology, physics,
Gerben Lassche, and Tim Frenzel, and Marcel H Mignot, and Marianne A Jonker, and Johannes G van der Hoeven, and Carla M L van Herpen, and Gert Jan Scheffer
Thermal tolerance to whole body hyperthermia.
June 1983, International journal of radiation oncology, biology, physics,
Gerben Lassche, and Tim Frenzel, and Marcel H Mignot, and Marianne A Jonker, and Johannes G van der Hoeven, and Carla M L van Herpen, and Gert Jan Scheffer
[Effects of extracorporeally induced systemic hyperthermia on cell-mediated immunity].
December 1983, Nihon Geka Gakkai zasshi,
Gerben Lassche, and Tim Frenzel, and Marcel H Mignot, and Marianne A Jonker, and Johannes G van der Hoeven, and Carla M L van Herpen, and Gert Jan Scheffer
Immunological and physiological responses to whole-body hyperthermia.
June 1982, National Cancer Institute monograph,
Gerben Lassche, and Tim Frenzel, and Marcel H Mignot, and Marianne A Jonker, and Johannes G van der Hoeven, and Carla M L van Herpen, and Gert Jan Scheffer
Effect of extracorporeally induced total body hyperthermia for cancer on cardiovascular function.
November 1984, Japanese heart journal,
Gerben Lassche, and Tim Frenzel, and Marcel H Mignot, and Marianne A Jonker, and Johannes G van der Hoeven, and Carla M L van Herpen, and Gert Jan Scheffer
Physiological studies of whole-body hyperthermia of dogs.
June 1985, Cancer research,
Gerben Lassche, and Tim Frenzel, and Marcel H Mignot, and Marianne A Jonker, and Johannes G van der Hoeven, and Carla M L van Herpen, and Gert Jan Scheffer
Hematological effects of radiant heat-induced whole body hyperthermia on dogs.
January 1996, Canadian journal of veterinary research = Revue canadienne de recherche veterinaire,
Copied contents to your clipboard!