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Iron (Fe) and transferrin (TF) uptake by human peripheral blood lymphocytes stimulated in vitro with phytohemagglutinin was measured. Pulses of 59FeTF or 125I-TF were added to the cultures either at time 0 or 8 hr before the end of a 72-hr incubation. In time-course experiments, peak iron and transferrin uptake coincided with the peak of tritiated thymidine uptake taken as a measure of cellular activation. Iron, but not transferrin, was accumulated by the cells. Non-linear relationships existed between both iron and transferrin uptake and the degree of activation. Both rose markedly above basal levels only at a level of activation at least 50% of the maximum observed. The results suggest that although iron utilization is related to cellular activity, the uptake mechanism is only activated when an increased iron metabolism has exhausted internal stores.
P G Taylor, and
A Soyano, and
E Romano, and
M Layrisse
May 1992,
Experimental hematology,
P G Taylor, and
A Soyano, and
E Romano, and
M Layrisse
September 1983,
British journal of haematology,
P G Taylor, and
A Soyano, and
E Romano, and
M Layrisse
March 1986,
British journal of haematology,
P G Taylor, and
A Soyano, and
E Romano, and
M Layrisse
January 1975,
Cellular immunology,
P G Taylor, and
A Soyano, and
E Romano, and
M Layrisse
January 1981,
Laboratornoe delo,
P G Taylor, and
A Soyano, and
E Romano, and
M Layrisse
January 1976,
Annales d'immunologie,
P G Taylor, and
A Soyano, and
E Romano, and
M Layrisse
May 1979,
Transplantation,
P G Taylor, and
A Soyano, and
E Romano, and
M Layrisse
December 1980,
Biological trace element research,
P G Taylor, and
A Soyano, and
E Romano, and
M Layrisse
June 1987,
European journal of cell biology,
P G Taylor, and
A Soyano, and
E Romano, and
M Layrisse
January 1988,
Hereditas,
