Primary vaginal leiomyosarcoma: A case report with complete morphological, immunohistochemical and ultrastructural study. 2020

Enrico Vizza, and Vincenzo Petrozza, and Natale Porta, and Camilla Certelli, and Ezio Battaglione, and Giacomo Corrado, and Giuseppe Familiari, and Rosemarie Heyn
Department of Experimental Clinical Oncology, Gynecologic Oncology Unit, IRCCS - Regina Elena National Cancer Institute, Rome, Italy.

OBJECTIVE Primary vaginal leiomyosarcomas (LMS) are rare, easily recurrent tumours with an unknown etiology; the prognosis is poor and there is no consensus guideline on their management. METHODS A nodular, 25 × 23 x 28 mm-mass, infiltrating the urethra, was found in a 58-year-old woman. A biopsy showed a LMS of the vagina that was positive for vimentin, alpha-smooth muscle actin, caldesmon, desmin, p16 and p53. An anterior pelvic exenteration was performed. The sample was fixed and prepared for light microscopy, transmission and scanning electron microscopy, confirming the diagnosis of LMS. CONCLUSIONS Best outcomes occur when the tumour is small, localized, and can be removed surgically with wide, clear margins, as in this case. As there are different kinds of malignant mesenchymal tumours, biopsy followed by immunohistochemistry and electron microscopy still represents a good diagnostic choice and surgical resection is generally the gold standard in these cases.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D007890 Leiomyosarcoma A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865) Leiomyosarcoma, Epithelioid,Leiomyosarcoma, Myxoid,Epithelioid Leiomyosarcoma,Epithelioid Leiomyosarcomas,Leiomyosarcomas,Leiomyosarcomas, Epithelioid,Leiomyosarcomas, Myxoid,Myxoid Leiomyosarcoma,Myxoid Leiomyosarcomas
D008853 Microscopy The use of instrumentation and techniques for visualizing material and details that cannot be seen by the unaided eye. It is usually done by enlarging images, transmitted by light or electron beams, with optical or magnetic lenses that magnify the entire image field. With scanning microscopy, images are generated by collecting output from the specimen in a point-by-point fashion, on a magnified scale, as it is scanned by a narrow beam of light or electrons, a laser, a conductive probe, or a topographical probe. Compound Microscopy,Hand-Held Microscopy,Light Microscopy,Optical Microscopy,Simple Microscopy,Hand Held Microscopy,Microscopy, Compound,Microscopy, Hand-Held,Microscopy, Light,Microscopy, Optical,Microscopy, Simple
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001706 Biopsy Removal and pathologic examination of specimens from the living body. Biopsies
D014621 Vagina The genital canal in the female, extending from the UTERUS to the VULVA. (Stedman, 25th ed) Vaginas
D014625 Vaginal Neoplasms Tumors or cancer of the VAGINA. Cancer of Vagina,Vaginal Cancer,Cancer of the Vagina,Neoplasms, Vaginal,Vagina Cancer,Vagina Neoplasms,Cancer, Vagina,Cancer, Vaginal,Cancers, Vagina,Cancers, Vaginal,Neoplasm, Vagina,Neoplasm, Vaginal,Neoplasms, Vagina,Vagina Cancers,Vagina Neoplasm,Vaginal Cancers,Vaginal Neoplasm

Related Publications

Enrico Vizza, and Vincenzo Petrozza, and Natale Porta, and Camilla Certelli, and Ezio Battaglione, and Giacomo Corrado, and Giuseppe Familiari, and Rosemarie Heyn
September 1991, The American journal of surgical pathology,
Enrico Vizza, and Vincenzo Petrozza, and Natale Porta, and Camilla Certelli, and Ezio Battaglione, and Giacomo Corrado, and Giuseppe Familiari, and Rosemarie Heyn
September 1980, Journal of neurosurgery,
Enrico Vizza, and Vincenzo Petrozza, and Natale Porta, and Camilla Certelli, and Ezio Battaglione, and Giacomo Corrado, and Giuseppe Familiari, and Rosemarie Heyn
September 1991, Archives of pathology & laboratory medicine,
Enrico Vizza, and Vincenzo Petrozza, and Natale Porta, and Camilla Certelli, and Ezio Battaglione, and Giacomo Corrado, and Giuseppe Familiari, and Rosemarie Heyn
October 1989, American journal of clinical pathology,
Enrico Vizza, and Vincenzo Petrozza, and Natale Porta, and Camilla Certelli, and Ezio Battaglione, and Giacomo Corrado, and Giuseppe Familiari, and Rosemarie Heyn
December 1999, Revue de chirurgie orthopedique et reparatrice de l'appareil moteur,
Enrico Vizza, and Vincenzo Petrozza, and Natale Porta, and Camilla Certelli, and Ezio Battaglione, and Giacomo Corrado, and Giuseppe Familiari, and Rosemarie Heyn
August 1983, Archives of pathology & laboratory medicine,
Enrico Vizza, and Vincenzo Petrozza, and Natale Porta, and Camilla Certelli, and Ezio Battaglione, and Giacomo Corrado, and Giuseppe Familiari, and Rosemarie Heyn
January 2013, Journal of cancer research and therapeutics,
Enrico Vizza, and Vincenzo Petrozza, and Natale Porta, and Camilla Certelli, and Ezio Battaglione, and Giacomo Corrado, and Giuseppe Familiari, and Rosemarie Heyn
February 1997, General & diagnostic pathology,
Enrico Vizza, and Vincenzo Petrozza, and Natale Porta, and Camilla Certelli, and Ezio Battaglione, and Giacomo Corrado, and Giuseppe Familiari, and Rosemarie Heyn
June 2015, Journal of medical case reports,
Enrico Vizza, and Vincenzo Petrozza, and Natale Porta, and Camilla Certelli, and Ezio Battaglione, and Giacomo Corrado, and Giuseppe Familiari, and Rosemarie Heyn
January 1995, Revue francaise de gynecologie et d'obstetrique,
Copied contents to your clipboard!