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Six new (1-6) and two known (7, 8) alkaloids that were chemically inseparable geometrical isomers (two isomers present in a 1:1 ratio for 1-4 and 6 and a 1:3 ratio for 5, 7, and 8) were identified from Stephania cepharantha. Their structures and absolute configurations were determined by spectroscopic data analyses and comparison of their experimental and calculated ECD spectra. Moreover, using NOE correlations and DFT-based calculations, the NMR data of each geometrical isomer of 1-6 were assigned. The biological evaluation of 1-8 showed that 5 and 6 have stronger inhibitory effects (IC50 values, 12.0 and 12.6 μM, respectively) than minocycline (IC50 value, 17.5 μM) against NO production in overactivated BV2 cells, suggesting they have great potential in the development of neuroinflammatory therapeutics for treating neurodegenerative diseases.
Jiao Xiao, and
Jun-Yu Song, and
Bin Lin, and
Wei Li, and
Yan-Qiu Yang, and
Jing-Yu Liu, and
Yue Hou, and
Gang Chen, and
Ning Li
March 2000,
Chemical & pharmaceutical bulletin,
Jiao Xiao, and
Jun-Yu Song, and
Bin Lin, and
Wei Li, and
Yan-Qiu Yang, and
Jing-Yu Liu, and
Yue Hou, and
Gang Chen, and
Ning Li
November 2023,
Natural product research,
Jiao Xiao, and
Jun-Yu Song, and
Bin Lin, and
Wei Li, and
Yan-Qiu Yang, and
Jing-Yu Liu, and
Yue Hou, and
Gang Chen, and
Ning Li
October 1993,
Planta medica,
Jiao Xiao, and
Jun-Yu Song, and
Bin Lin, and
Wei Li, and
Yan-Qiu Yang, and
Jing-Yu Liu, and
Yue Hou, and
Gang Chen, and
Ning Li
February 2011,
Journal of natural products,
Jiao Xiao, and
Jun-Yu Song, and
Bin Lin, and
Wei Li, and
Yan-Qiu Yang, and
Jing-Yu Liu, and
Yue Hou, and
Gang Chen, and
Ning Li
May 2010,
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Jiao Xiao, and
Jun-Yu Song, and
Bin Lin, and
Wei Li, and
Yan-Qiu Yang, and
Jing-Yu Liu, and
Yue Hou, and
Gang Chen, and
Ning Li
December 1969,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
Jiao Xiao, and
Jun-Yu Song, and
Bin Lin, and
Wei Li, and
Yan-Qiu Yang, and
Jing-Yu Liu, and
Yue Hou, and
Gang Chen, and
Ning Li
March 1999,
Biological & pharmaceutical bulletin,
Jiao Xiao, and
Jun-Yu Song, and
Bin Lin, and
Wei Li, and
Yan-Qiu Yang, and
Jing-Yu Liu, and
Yue Hou, and
Gang Chen, and
Ning Li
October 1990,
FEBS letters,
Jiao Xiao, and
Jun-Yu Song, and
Bin Lin, and
Wei Li, and
Yan-Qiu Yang, and
Jing-Yu Liu, and
Yue Hou, and
Gang Chen, and
Ning Li
April 2000,
Journal of natural products,
Jiao Xiao, and
Jun-Yu Song, and
Bin Lin, and
Wei Li, and
Yan-Qiu Yang, and
Jing-Yu Liu, and
Yue Hou, and
Gang Chen, and
Ning Li
October 1981,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
