Aldosterone renin ratio and chronic kidney disease. 2020

Wessam Osman, and Hayam Al Dohani, and Al Shaima Al Hinai, and Suad Hannawi, and Faissal A M Shaheen, and Issa Al Salmi
Department of Internal Medicine, The Royal Hospital, Muscat, Oman.

As a component of the metabolic syndrome, hypertension (HTN) is increasing throughout the world with variable percentages, but mostly among developing world. Aldosterone plays a role in the relationship between aldosterone and nephropathy. We aimed to evaluate the relationship between aldosterone renin ratio (ARR) and chronic kidney disease (CKD). Variables drawn from the computerized hospital information database were all patients who had an ARR above 35 (if aldosterone reading was above 300 pmol/L). A total of 1584 patients, of whom 777 were male and 807 were female, with a mean [standard deviation (SD)] of 43.3 (16.5) years were studied. The mean ARR was 210.1 (SD: 246.4) in males and 214.3 and 210.1 in females, P = 0.51. The mean estimated glomerular filtration rate (eGFR) was 50.2 (SD 12.6); in males, it was 49.99 (0.90) and in females, it was 50.48 (0.92), P = 0.70. The regression model revealed a negative relationship between ARR and GFR with a coefficient of -2.08, 95% confidence interval: -4.6, 0.21, P = 0.07. CKD population with HTN tends to have a very high level of ARR, and those with advanced CKD have higher ARR. However, high ARR could have low eGFR and kidney dysfunction on follow-up. In view of high prevalence of noncommunicable disease and high early CKD population, there is an important need to consider comprehensive management strategies that involve the blockage of high renin-angiotensin-aldosterone and the use of mineralocorticosteroid receptor blockers.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D012083 Renin A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19. Angiotensin-Forming Enzyme,Angiotensinogenase,Big Renin,Cryorenin,Inactive Renin,Pre-Prorenin,Preprorenin,Prorenin,Angiotensin Forming Enzyme,Pre Prorenin,Renin, Big,Renin, Inactive
D005260 Female Females
D005919 Glomerular Filtration Rate The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance. Filtration Rate, Glomerular,Filtration Rates, Glomerular,Glomerular Filtration Rates,Rate, Glomerular Filtration,Rates, Glomerular Filtration
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000450 Aldosterone A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. Aldosterone, (+-)-Isomer,Aldosterone, (11 beta,17 alpha)-Isomer
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective

Related Publications

Wessam Osman, and Hayam Al Dohani, and Al Shaima Al Hinai, and Suad Hannawi, and Faissal A M Shaheen, and Issa Al Salmi
January 2015, International journal of clinical and experimental pathology,
Wessam Osman, and Hayam Al Dohani, and Al Shaima Al Hinai, and Suad Hannawi, and Faissal A M Shaheen, and Issa Al Salmi
August 2012, Journal of hypertension,
Wessam Osman, and Hayam Al Dohani, and Al Shaima Al Hinai, and Suad Hannawi, and Faissal A M Shaheen, and Issa Al Salmi
November 2011, Journal of hypertension,
Wessam Osman, and Hayam Al Dohani, and Al Shaima Al Hinai, and Suad Hannawi, and Faissal A M Shaheen, and Issa Al Salmi
October 2015, Nutrition, metabolism, and cardiovascular diseases : NMCD,
Wessam Osman, and Hayam Al Dohani, and Al Shaima Al Hinai, and Suad Hannawi, and Faissal A M Shaheen, and Issa Al Salmi
March 2009, Translational research : the journal of laboratory and clinical medicine,
Wessam Osman, and Hayam Al Dohani, and Al Shaima Al Hinai, and Suad Hannawi, and Faissal A M Shaheen, and Issa Al Salmi
February 2014, Journal of the American College of Cardiology,
Wessam Osman, and Hayam Al Dohani, and Al Shaima Al Hinai, and Suad Hannawi, and Faissal A M Shaheen, and Issa Al Salmi
November 2021, American journal of cardiovascular drugs : drugs, devices, and other interventions,
Wessam Osman, and Hayam Al Dohani, and Al Shaima Al Hinai, and Suad Hannawi, and Faissal A M Shaheen, and Issa Al Salmi
January 2010, American journal of nephrology,
Wessam Osman, and Hayam Al Dohani, and Al Shaima Al Hinai, and Suad Hannawi, and Faissal A M Shaheen, and Issa Al Salmi
January 2023, Frontiers in pharmacology,
Wessam Osman, and Hayam Al Dohani, and Al Shaima Al Hinai, and Suad Hannawi, and Faissal A M Shaheen, and Issa Al Salmi
May 2003, Expert review of cardiovascular therapy,
Copied contents to your clipboard!