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The disposition of fenbendazole (FBZ) was studied in vivo in cattle (steers), goats, chickens, ducks, turkeys and rabbits, and in vitro in hepatic enzyme preparations from cattle, sheep, goats, rabbits, rats, chickens, ducks, turkeys and catfish. The major excretory metabolite when FBZ was administered either iv or po (5 mg/kg) was p-hydroxyfenbendazole (FBZ-OH). The sulfoxide (FBZ-SO) and sulfone (FBZ-SO2) appeared in plasma but were recovered in only trace amounts in urine or feces, and the amine (FBZ-NH2) was a minor metabolite appearing only occasionally in plasma. The greatest species differences were seen among the avian species, and differences in metabolite excretion correlated well with the ability of the species to metabolize the drug (especially to FBZ-OH) in vitro. Other in vitro studies measured the rate of oxidative, hydrolytic, and conjugative (glucuronide, acetate, sulfate) pathways in liver preparations.
C R Short, and
S A Barker, and
W Flory
January 1988,
Veterinary and human toxicology,
C R Short, and
S A Barker, and
W Flory
February 1994,
Veterinary and human toxicology,
C R Short, and
S A Barker, and
W Flory
January 1993,
Veterinary and human toxicology,
C R Short, and
S A Barker, and
W Flory
June 2003,
Fundamental & clinical pharmacology,
C R Short, and
S A Barker, and
W Flory
January 1983,
Journal of chronic diseases,
C R Short, and
S A Barker, and
W Flory
January 2022,
International journal of tryptophan research : IJTR,
C R Short, and
S A Barker, and
W Flory
September 2013,
The Veterinary clinics of North America. Small animal practice,
C R Short, and
S A Barker, and
W Flory
June 1996,
Xenobiotica; the fate of foreign compounds in biological systems,
C R Short, and
S A Barker, and
W Flory
March 1993,
Arzneimittel-Forschung,
C R Short, and
S A Barker, and
W Flory
January 1986,
Veterinary and human toxicology,
