BIOMAT Database Logo BIOMAT Database Logo

One year's treatment of Paget's disease of bone by synthetic salmon calcitonin as a nasal spray. 1988

J Y Reginster, and A M Jeugmans-Huynen, and A Albert, and D Denis, and P Franchimont
Rheumatology, Physical Medicine and Rehabilitation Department, University of Liège, Belgium.

The effectiveness of synthetic salmon calcitonin (SCT) administered as a nasal spray was assessed via clinical, biological, and radiological variables in 17 previously untreated Pagetic patients over a 1-year course of therapy. The results showed a highly significant decrease of serum alkaline phosphatase (S-ALP) (p less than 0.05 after 1 month of treatment) and of the urinary hydroxyproline/creatinine ratio (OH/Cr) (p less than 0.01 after 1 month of treatment). For the whole group, the mean decrease in S-ALP was 37 +/- 4% (SEM) after 6 months (p less than 0.01) and 31 +/- 5% after 1 year (p less than 0.01). The mean fall in OH/Cr was 35 +/- 6% (SEM) (p less than 0.01) and 37 +/- 7% (p less than 0.01) after 6 and 12 months, respectively. None of the usual side-effects of SCT were reported and local tolerance was excellent throughout the study.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010001 Osteitis Deformans A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry. Paget's Disease of Bone,Osseous Paget's Disease,Paget Disease of Bone,Paget Disease, Bone,Pagets Disease, Bone
D002116 Calcitonin A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults. Thyrocalcitonin,Calcitonin(1-32),Calcitrin,Ciba 47175-BA,Eel Calcitonin,Calcitonin, Eel,Ciba 47175 BA,Ciba 47175BA
D003404 Creatinine Creatinine Sulfate Salt,Krebiozen,Salt, Creatinine Sulfate,Sulfate Salt, Creatinine
D005260 Female Females
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006909 Hydroxyproline A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation. Oxyproline,4-Hydroxyproline,cis-4-Hydroxyproline,4 Hydroxyproline,cis 4 Hydroxyproline
D000281 Administration, Intranasal Delivery of medications through the nasal mucosa. Drug Administration, Intranasal,Administration, Intranasal Drug,Administration, Nasal,Intranasal Administration,Intranasal Drug Administration,Administrations, Intranasal,Administrations, Intranasal Drug,Administrations, Nasal,Drug Administrations, Intranasal,Intranasal Administrations,Intranasal Drug Administrations,Nasal Administration,Nasal Administrations

Related Publications

J Y Reginster, and A M Jeugmans-Huynen, and A Albert, and D Denis, and P Franchimont
Treatment of Paget's disease of bone with salmon calcitonin nasal spray.
November 1988, Journal of the American Geriatrics Society,
J Y Reginster, and A M Jeugmans-Huynen, and A Albert, and D Denis, and P Franchimont
[Salmon calcitonin nasal spray in the treatment of Paget's disease].
November 1989, Recenti progressi in medicina,
J Y Reginster, and A M Jeugmans-Huynen, and A Albert, and D Denis, and P Franchimont
Treatment of Paget's disease of bone with synthetic salmon calcitonin.
September 1974, British medical journal,
J Y Reginster, and A M Jeugmans-Huynen, and A Albert, and D Denis, and P Franchimont
[Paget's disease of bone and calcitonin nasal spray].
June 1986, Medicina clinica,
J Y Reginster, and A M Jeugmans-Huynen, and A Albert, and D Denis, and P Franchimont
Salmon-calcitonin nasal spray in Paget's disease of bone: preliminary results in five patients.
December 1985, Calcified tissue international,
J Y Reginster, and A M Jeugmans-Huynen, and A Albert, and D Denis, and P Franchimont
[Calcitonin nasal spray for Paget's disease of the bone].
March 1995, Harefuah,
J Y Reginster, and A M Jeugmans-Huynen, and A Albert, and D Denis, and P Franchimont
[Treatment of Paget's disease of bone using synthetic salmon calcitonin administered intranasally].
January 1986, Revue medicale de Liege,
J Y Reginster, and A M Jeugmans-Huynen, and A Albert, and D Denis, and P Franchimont
Metabolic effects of synthetic salmon calcitonin in Paget's disease of bone.
November 1974, Metabolism: clinical and experimental,
J Y Reginster, and A M Jeugmans-Huynen, and A Albert, and D Denis, and P Franchimont
Treatment of Paget's disease of bone with salmon calcitonin.
January 1976, Acta clinica Belgica,
J Y Reginster, and A M Jeugmans-Huynen, and A Albert, and D Denis, and P Franchimont
Synthetic salmon calcitonin. Treatment of Paget's disease and osteogenesis imperfecta.
September 1972, JAMA,
Copied contents to your clipboard!