Outcomes of Endovascular Thrombectomy for Basilar Artery Occlusion. 2020

Christopher R Pasarikovski, and Houman Khosravani, and Leodante da Costa, and Chinthaka Heyn, and Stefano M Priola, and Jerry C Ku, and Sandra E Black, and David J Gladstone, and Victor X D Yang
Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

Large prospective observational studies have cast doubt on the common assumption that endovascular thrombectomy (EVT) is superior to intravenous thrombolysis for patients with acute basilar artery occlusion (BAO). The purpose of this study was to retrospectively review our experience for patients with BAO undergoing EVT with modern endovascular devices. All consecutive patients undergoing EVT with either a second-generation stent retriever or direct aspiration thrombectomy for BAO at our regional stroke center from January 1, 2013 to March 1, 2019 were included. The primary outcome measure was functional outcome at 1 month using the modified Rankin Scale (mRS) score. Multivariable logistic regression was used to assess the association between patient characteristics and dichotomized mRS. A total of 43 consecutive patients underwent EVT for BAO. The average age was 67 years with 61% male patients. Overall, 37% (16/43) of patients achieved good functional outcome. Successful reperfusion was achieved in 72% (31/43) of cases. The median (interquartile range) stroke onset to treatment time was 420 (270-639) minutes (7 hours) for all patients. The procedure-related complication rate was 9% (4/43). On multivariate analysis, posterior circulation Alberta stroke program early computed tomography score and Basilar Artery on Computed Tomography Angiography score were associated with improved functional outcome. EVT appears to be safe and feasible in patients with BAO. Our finding that time to treatment and successful reperfusion were not associated with improved outcome is likely due to including patients with established infarcts. Given the variability of collaterals in the posterior circulation, the paradigm of utilizing a tissue window may assist in patient selection for EVT. Magnetic resonance imaging may be a reasonable option to determine the extent of ischemia in certain situations.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000369 Aged, 80 and over Persons 80 years of age and older. Oldest Old
D001488 Basilar Artery The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries. Arteries, Basilar,Artery, Basilar,Basilar Arteries
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D014715 Vertebrobasilar Insufficiency Localized or diffuse reduction in blood flow through the vertebrobasilar arterial system, which supplies the BRAIN STEM; CEREBELLUM; OCCIPITAL LOBE; medial TEMPORAL LOBE; and THALAMUS. Characteristic clinical features include SYNCOPE; lightheadedness; visual disturbances; and VERTIGO. BRAIN STEM INFARCTIONS or other BRAIN INFARCTION may be associated. Basilar Artery Insufficiency,Basilar Artery Stenosis,Vertebral Artery Insufficiency,Vertebral Artery Stenosis,Basilar Artery Ischemia,Basilar Insufficiency,Vertebral Artery Ischemia,Vertebro-Basilar Insufficiency,Vertebro-Basilar Ischemia,Vertebrobasilar Dolichoectasia,Vertebrobasilar Ischemia,Artery Insufficiencies, Basilar,Artery Insufficiencies, Vertebral,Artery Insufficiency, Basilar,Artery Insufficiency, Vertebral,Artery Ischemia, Basilar,Artery Ischemia, Vertebral,Artery Ischemias, Basilar,Artery Ischemias, Vertebral,Artery Stenoses, Basilar,Artery Stenoses, Vertebral,Artery Stenosis, Basilar,Artery Stenosis, Vertebral,Basilar Artery Insufficiencies,Basilar Artery Ischemias,Basilar Artery Stenoses,Basilar Insufficiencies,Dolichoectasia, Vertebrobasilar,Dolichoectasias, Vertebrobasilar,Insufficiencies, Basilar,Insufficiencies, Basilar Artery,Insufficiencies, Vertebral Artery,Insufficiencies, Vertebro-Basilar,Insufficiencies, Vertebrobasilar,Insufficiency, Basilar,Insufficiency, Basilar Artery,Insufficiency, Vertebral Artery,Insufficiency, Vertebro-Basilar,Insufficiency, Vertebrobasilar,Ischemia, Basilar Artery,Ischemia, Vertebral Artery,Ischemia, Vertebro-Basilar,Ischemia, Vertebrobasilar,Ischemias, Basilar Artery,Ischemias, Vertebral Artery,Ischemias, Vertebro-Basilar,Ischemias, Vertebrobasilar,Stenoses, Basilar Artery,Stenoses, Vertebral Artery,Stenosis, Basilar Artery,Stenosis, Vertebral Artery,Vertebral Artery Insufficiencies,Vertebral Artery Ischemias,Vertebral Artery Stenoses,Vertebro Basilar Insufficiency,Vertebro Basilar Ischemia,Vertebro-Basilar Insufficiencies,Vertebro-Basilar Ischemias,Vertebrobasilar Dolichoectasias,Vertebrobasilar Insufficiencies,Vertebrobasilar Ischemias
D016896 Treatment Outcome Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series. Rehabilitation Outcome,Treatment Effectiveness,Clinical Effectiveness,Clinical Efficacy,Patient-Relevant Outcome,Treatment Efficacy,Effectiveness, Clinical,Effectiveness, Treatment,Efficacy, Clinical,Efficacy, Treatment,Outcome, Patient-Relevant,Outcome, Rehabilitation,Outcome, Treatment,Outcomes, Patient-Relevant,Patient Relevant Outcome,Patient-Relevant Outcomes

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