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IgA rheumatoid factor, IgA and IgG immune complexes were measured in 119 patients with IgA nephropathy. IgA rheumatoid factor was detected in 62/119 (52%) patients and in 92/265 (35%) serum samples. There was a good correlation (p less than 0.001) between the presence of IgA rheumatoid factor and the presence as well as levels of IgG immune complexes, but not between levels of IgA rheumatoid factor and other clinical or immunological parameters. However, higher levels of serum IgA were found in the subgroup of patients with constantly positive IgA rheumatoid factor. Using aggregated human IgG, we could not demonstrate antiglobulin activity in renal biopsy specimens from 36 patients. These results suggest that IgA rheumatoid factor does not play a primary role in renal damage in IgA nephropathy, but could simply reflect a response to IgG immune complexes in a disorder characterized by abnormalities of IgA production. Nevertheless, the presence of circulating IgA rheumatoid factor in a substantial proportion of patients, especially in those with features of polyclonal IgA activation, provides additional evidence for a general perturbation of IgA metabolism in this disease and could represent an antigen-specific system with which to study regulation of IgA synthesis.
R A Sinico, and
A Fornasieri, and
P Maldifassi, and
G Colasanti, and
G D'Amico
January 1985,
American journal of nephrology,
R A Sinico, and
A Fornasieri, and
P Maldifassi, and
G Colasanti, and
G D'Amico
January 1990,
Revista do Hospital das Clinicas,
R A Sinico, and
A Fornasieri, and
P Maldifassi, and
G Colasanti, and
G D'Amico
January 1988,
Revista do Hospital das Clinicas,
R A Sinico, and
A Fornasieri, and
P Maldifassi, and
G Colasanti, and
G D'Amico
January 1989,
Revista do Hospital das Clinicas,
R A Sinico, and
A Fornasieri, and
P Maldifassi, and
G Colasanti, and
G D'Amico
February 1990,
Revista medica de Chile,
R A Sinico, and
A Fornasieri, and
P Maldifassi, and
G Colasanti, and
G D'Amico
January 1984,
Contributions to nephrology,
R A Sinico, and
A Fornasieri, and
P Maldifassi, and
G Colasanti, and
G D'Amico
November 1981,
Clinical nephrology,
R A Sinico, and
A Fornasieri, and
P Maldifassi, and
G Colasanti, and
G D'Amico
January 1985,
Revista de medicina interna, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicina interna,
R A Sinico, and
A Fornasieri, and
P Maldifassi, and
G Colasanti, and
G D'Amico
January 1985,
Nephron,
R A Sinico, and
A Fornasieri, and
P Maldifassi, and
G Colasanti, and
G D'Amico
December 1992,
Boletin medico del Hospital Infantil de Mexico,
