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Non-Hodgkin Lymphomas: Malignancies Arising from Mature B Cells. 2021
Jennifer Shingleton, and
Jie Wang, and
Carolyn Baloh, and
Tushar Dave, and
Nicholas Davis, and
Lanie Happ, and
Othmane Jadi, and
Rachel Kositsky, and
Xiang Li, and
Cassandra Love, and
Razvan Panea, and
Qiu Qin, and
Anupama Reddy, and
Naina Singhi, and
Eileen Smith, and
Devang Thakkar, and
Sandeep S Dave
Department of Medicine and Center for Genomic and Computational Biology, Duke Cancer Institute, Duke University, Durham, North Carolina 27707, USA.
Non-Hodgkin lymphomas (NHLs) are a diverse group of entities, both clinically and molecularly. Here, we review the evolution of classification schemes in B-cell lymphoma, noting the now standard WHO classification system that is based on immune cell-of-origin and molecular phenotypes. We review how lymphomas arise throughout the B-cell development process as well as the molecular and clinical features of prominent B-cell lymphomas. We provide an overview of the major progress that has occurred over the past decade in terms of our molecular understanding of these diseases. We discuss treatment options available and focus on a number of the diverse research tools that have been employed to improve our understanding of these diseases. We discuss the problem of heterogeneity in lymphomas and anticipate that the near future will bring significant advances that provide a measurable impact on NHL outcomes.
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