Biomaterial Database

Evidence for an A2 adenosine receptor in human coronary arteries. 1988

M V Ramagopal, and R W Chitwood, and S J Mustafa

Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC 27858-4354.

The present study was an attempt to characterize the type of adenosine receptor in human coronary arteries obtained from organ donors with the use of adenosine analogs. Prostaglandin F2 alpha (10(-6) M) produced tonic contractions followed by phasic contractions and diltiazem (10(-6) M) pretreatment changed the phasic contractions to tonic contractions. Adenosine and its analogs (5'-N-ethyl-carboxamide adenosine, NECA and N6-L-phenyl-isopropyl adenosine, L-PIA), produced concentration-dependent relaxations of the tonic contractions and the order of potency was found to be: NECA greater than L-PIA greater than adenosine. 8-Phenyltheophylline (5 X 10(-6) M) antagonized the relaxations produced by adenosine and its analogs. The data suggest the existence of A2 adenosine receptor in human coronary arteries.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009126	Muscle Relaxation	That phase of a muscle twitch during which a muscle returns to a resting position.	Muscle Relaxations,Relaxation, Muscle,Relaxations, Muscle
D009131	Muscle, Smooth, Vascular	The nonstriated involuntary muscle tissue of blood vessels.	Vascular Smooth Muscle,Muscle, Vascular Smooth,Muscles, Vascular Smooth,Smooth Muscle, Vascular,Smooth Muscles, Vascular,Vascular Smooth Muscles
D010660	Phenylisopropyladenosine	N-Isopropyl-N-phenyl-adenosine. Antilipemic agent. Synonym: TH 162.	Isopropylphenyladenosine,L-Phenylisopropyladenosine,N(6)-Phenylisopropyl-Adenosine,L Phenylisopropyladenosine
D011983	Receptors, Purinergic	Cell surface proteins that bind PURINES with high affinity and trigger intracellular changes which influence the behavior of cells. The best characterized classes of purinergic receptors in mammals are the P1 receptors, which prefer ADENOSINE, and the P2 receptors, which prefer ATP or ADP.	Methyladenine Receptors,Purine Receptors,Purinergic Receptor,Purinergic Receptors,Purinoceptors,Purine Receptor,Purinoceptor,Receptors, Methyladenine,Receptors, Purine,Receptor, Purine,Receptor, Purinergic
D003331	Coronary Vessels	The veins and arteries of the HEART.	Coronary Arteries,Sinus Node Artery,Coronary Veins,Arteries, Coronary,Arteries, Sinus Node,Artery, Coronary,Artery, Sinus Node,Coronary Artery,Coronary Vein,Coronary Vessel,Sinus Node Arteries,Vein, Coronary,Veins, Coronary,Vessel, Coronary,Vessels, Coronary
D004110	Diltiazem	A benzothiazepine derivative with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.	Aldizem,CRD-401,Cardil,Cardizem,Dilacor,Dilacor XR,Dilren,Diltiazem Hydrochloride,Diltiazem Malate,Dilzem,Tiazac,CRD 401,CRD401
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000241	Adenosine	A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.	Adenocard,Adenoscan
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults