Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery. 2020

Klazina Kooiman, and Silke Roovers, and Simone A G Langeveld, and Robert T Kleven, and Heleen Dewitte, and Meaghan A O'Reilly, and Jean-Michel Escoffre, and Ayache Bouakaz, and Martin D Verweij, and Kullervo Hynynen, and Ine Lentacker, and Eleanor Stride, and Christy K Holland
Department of Biomedical Engineering, Thoraxcenter, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands. Electronic address: k.kooiman@erasmusmc.nl.

Therapeutic ultrasound strategies that harness the mechanical activity of cavitation nuclei for beneficial tissue bio-effects are actively under development. The mechanical oscillations of circulating microbubbles, the most widely investigated cavitation nuclei, which may also encapsulate or shield a therapeutic agent in the bloodstream, trigger and promote localized uptake. Oscillating microbubbles can create stresses either on nearby tissue or in surrounding fluid to enhance drug penetration and efficacy in the brain, spinal cord, vasculature, immune system, biofilm or tumors. This review summarizes recent investigations that have elucidated interactions of ultrasound and cavitation nuclei with cells, the treatment of tumors, immunotherapy, the blood-brain and blood-spinal cord barriers, sonothrombolysis, cardiovascular drug delivery and sonobactericide. In particular, an overview of salient ultrasound features, drug delivery vehicles, therapeutic transport routes and pre-clinical and clinical studies is provided. Successful implementation of ultrasound and cavitation nuclei-mediated drug delivery has the potential to change the way drugs are administered systemically, resulting in more effective therapeutics and less-invasive treatments.

UI MeSH Term Description Entries
D007167 Immunotherapy Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection. Immunotherapies
D009369 Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D001812 Blood-Brain Barrier Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue. Brain-Blood Barrier,Hemato-Encephalic Barrier,Barrier, Blood-Brain,Barrier, Brain-Blood,Barrier, Hemato-Encephalic,Barriers, Blood-Brain,Barriers, Brain-Blood,Barriers, Hemato-Encephalic,Blood Brain Barrier,Blood-Brain Barriers,Brain Blood Barrier,Brain-Blood Barriers,Hemato Encephalic Barrier,Hemato-Encephalic Barriers
D002317 Cardiovascular Agents Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume. Cardioactive Agent,Cardioactive Drug,Cardiovascular Agent,Cardiovascular Drug,Cardioactive Agents,Cardioactive Drugs,Cardiovascular Drugs,Agent, Cardioactive,Agent, Cardiovascular,Drug, Cardioactive,Drug, Cardiovascular
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001424 Bacterial Infections Infections by bacteria, general or unspecified. Bacterial Disease,Bacterial Infection,Infection, Bacterial,Infections, Bacterial,Bacterial Diseases
D014464 Ultrasonic Therapy The use of focused, high-frequency sound waves to produce local hyperthermia in certain diseased or injured parts of the body or to destroy the diseased tissue. Therapeutic Ultrasound,Ultrasound Therapy,Therapy, Ultrasonic,Therapies, Ultrasonic,Therapies, Ultrasound,Therapy, Ultrasound,Ultrasonic Therapies,Ultrasound Therapies,Ultrasound, Therapeutic
D015912 Thrombolytic Therapy Use of infusions of FIBRINOLYTIC AGENTS to destroy or dissolve thrombi in blood vessels or bypass grafts. Fibrinolytic Therapy,Thrombolysis, Therapeutic,Therapeutic Thrombolysis,Therapy, Fibrinolytic,Therapy, Thrombolytic,Fibrinolytic Therapies,Therapeutic Thrombolyses,Therapies, Fibrinolytic,Therapies, Thrombolytic,Thrombolyses, Therapeutic,Thrombolytic Therapies
D016503 Drug Delivery Systems Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity. Drug Targeting,Delivery System, Drug,Delivery Systems, Drug,Drug Delivery System,Drug Targetings,System, Drug Delivery,Systems, Drug Delivery,Targeting, Drug,Targetings, Drug
D045423 Microbubbles Small encapsulated gas bubbles (diameters of micrometers) that can be used as CONTRAST MEDIA, and in other diagnostic and therapeutic applications. Upon exposure to sufficiently intense ultrasound, microbubbles will cavitate, rupture, disappear, release gas content. Such characteristics of the microbubbles can be used to enhance diagnostic tests, dissolve blood clots, and deliver drugs or genes for therapy. Colloidal Gas Aphrons,Aphron, Colloidal Gas,Aphrons, Colloidal Gas,Colloidal Gas Aphron,Gas Aphron, Colloidal,Gas Aphrons, Colloidal,Microbubble

Related Publications

Klazina Kooiman, and Silke Roovers, and Simone A G Langeveld, and Robert T Kleven, and Heleen Dewitte, and Meaghan A O'Reilly, and Jean-Michel Escoffre, and Ayache Bouakaz, and Martin D Verweij, and Kullervo Hynynen, and Ine Lentacker, and Eleanor Stride, and Christy K Holland
March 2022, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI),
Klazina Kooiman, and Silke Roovers, and Simone A G Langeveld, and Robert T Kleven, and Heleen Dewitte, and Meaghan A O'Reilly, and Jean-Michel Escoffre, and Ayache Bouakaz, and Martin D Verweij, and Kullervo Hynynen, and Ine Lentacker, and Eleanor Stride, and Christy K Holland
May 2024, ACS applied materials & interfaces,
Klazina Kooiman, and Silke Roovers, and Simone A G Langeveld, and Robert T Kleven, and Heleen Dewitte, and Meaghan A O'Reilly, and Jean-Michel Escoffre, and Ayache Bouakaz, and Martin D Verweij, and Kullervo Hynynen, and Ine Lentacker, and Eleanor Stride, and Christy K Holland
January 2019, Frontiers in pharmacology,
Klazina Kooiman, and Silke Roovers, and Simone A G Langeveld, and Robert T Kleven, and Heleen Dewitte, and Meaghan A O'Reilly, and Jean-Michel Escoffre, and Ayache Bouakaz, and Martin D Verweij, and Kullervo Hynynen, and Ine Lentacker, and Eleanor Stride, and Christy K Holland
April 2019, IEEE transactions on ultrasonics, ferroelectrics, and frequency control,
Klazina Kooiman, and Silke Roovers, and Simone A G Langeveld, and Robert T Kleven, and Heleen Dewitte, and Meaghan A O'Reilly, and Jean-Michel Escoffre, and Ayache Bouakaz, and Martin D Verweij, and Kullervo Hynynen, and Ine Lentacker, and Eleanor Stride, and Christy K Holland
November 2006, Expert opinion on drug delivery,
Klazina Kooiman, and Silke Roovers, and Simone A G Langeveld, and Robert T Kleven, and Heleen Dewitte, and Meaghan A O'Reilly, and Jean-Michel Escoffre, and Ayache Bouakaz, and Martin D Verweij, and Kullervo Hynynen, and Ine Lentacker, and Eleanor Stride, and Christy K Holland
September 2023, Biomaterials science,
Klazina Kooiman, and Silke Roovers, and Simone A G Langeveld, and Robert T Kleven, and Heleen Dewitte, and Meaghan A O'Reilly, and Jean-Michel Escoffre, and Ayache Bouakaz, and Martin D Verweij, and Kullervo Hynynen, and Ine Lentacker, and Eleanor Stride, and Christy K Holland
June 2022, Pharmaceutics,
Klazina Kooiman, and Silke Roovers, and Simone A G Langeveld, and Robert T Kleven, and Heleen Dewitte, and Meaghan A O'Reilly, and Jean-Michel Escoffre, and Ayache Bouakaz, and Martin D Verweij, and Kullervo Hynynen, and Ine Lentacker, and Eleanor Stride, and Christy K Holland
October 2020, Journal of cardiovascular pharmacology,
Klazina Kooiman, and Silke Roovers, and Simone A G Langeveld, and Robert T Kleven, and Heleen Dewitte, and Meaghan A O'Reilly, and Jean-Michel Escoffre, and Ayache Bouakaz, and Martin D Verweij, and Kullervo Hynynen, and Ine Lentacker, and Eleanor Stride, and Christy K Holland
July 2021, Pharmaceutics,
Klazina Kooiman, and Silke Roovers, and Simone A G Langeveld, and Robert T Kleven, and Heleen Dewitte, and Meaghan A O'Reilly, and Jean-Michel Escoffre, and Ayache Bouakaz, and Martin D Verweij, and Kullervo Hynynen, and Ine Lentacker, and Eleanor Stride, and Christy K Holland
March 2018, Advanced healthcare materials,
Copied contents to your clipboard!