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Minocycline-induced hyperpigmentation: rapid resolution after 755nm alexandrite picosecond laser treatment. 2020

Jason K Rivers, and Misha Zarbafian, and Brianne Vestvik, and Sara Kawamura, and Marcie Ulmer, and L Alexandra Kuritzky
Pacific Derm, Vancouver, British Columbia, Canada.

Minocycline-induced pigmentation (MIP) is an infrequent complication of minocycline therapy, with four subtypes each with distinct clinical features and histologic staining patterns. MIP may resolve following discontinuation of minocycline therapy or it may persist indefinitely. A 64-year-old Caucasian male presented with a 6 month history of progressive blue-gray facial pigmentation distributed symmetrically over his face. One session utilizing a 755 nm picosecond Alexandrite laser resulted in immediate and significant clearance of the pigment in all treated areas. Long-term follow-up at 2 years revealed no recurrence of the MIP.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D008911 Minocycline A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections. Akamin,Akne-Puren,Aknemin,Aknin-Mino,Aknosan,Apo-Minocycline,Arestin,Blemix,Cyclomin,Cyclops,Dentomycin,Dynacin,Icht-Oral,Klinomycin,Lederderm,Mestacine,Minakne,Mino-Wolff,Minocin,Minocin MR,Minoclir,Minocycline Hydrochloride,Minocycline Monohydrochloride,Minocycline, (4R-(4 alpha,4a beta,5a beta,12a beta))-Isomer,Minolis,Minomycin,Minoplus,Minotab,Minox 50,Mynocine,Akne Puren,Aknin Mino,Apo Minocycline,Hydrochloride, Minocycline,Icht Oral,Mino Wolff,Monohydrochloride, Minocycline
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D017495 Hyperpigmentation Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance. Hypermelanosis,Hypermelanoses
D053844 Lasers, Solid-State Lasers which use a solid, as opposed to a liquid or gas, as the lasing medium. Common materials used are crystals, such as YAG (YTTRIUM aluminum garnet); alexandrite; and CORUNDUM, doped with a rare earth element such as a NEODYMIUM; ERBIUM; or HOLMIUM. The output is sometimes additionally modified by addition of non-linear optical materials such as potassium titanyl phosphate crystal, which for example is used with neodymium YAG lasers to convert the output light to the visible range. Alexandrite Laser,Alexandrite Lasers,Diode Pumped Solid State Laser,Diode Pumped Solid State Lasers,Er-YAG Laser,Er-YAG Lasers,Erbium Doped Yttrium Aluminum Garnet Laser,Erbium YAG Laser,Erbium-Doped Yttrium Aluminum Garnet Laser,Erbium-Doped Yttrium Aluminum Garnet Lasers,Ho YAG Laser,Ho YAG Lasers,Holmium Doped Yttrium Aluminum Garnet Lasers,Holmium Laser,Holmium-YAG Laser,Holmium-YAG Lasers,KTP Laser,Laser, Nd-YAG,Nd-YAG Laser,Nd-YAG Lasers,Neodymium-Doped Yttrium Aluminum Garnet Laser,Neodymium-Doped Yttrium Aluminum Garnet Lasers,Potassium Titanyl Phosphate Laser,Ruby Laser,Ruby Lasers,Solid-State Laser,YAG Laser,YAG Lasers,YLF Laser,YLF Lasers,YSGG Laser,YSGG Lasers,Yttrium Aluminum Garnet Laser,Yttrium-Lithium-Fluoride Laser,Yttrium-Lithium-Fluoride Lasers,Yttrium-Scandium-Gallium Garnet Laser,Yttrium-Scandium-Gallium Garnet Lasers,Erbium YAG Lasers,Holmium Lasers,KTP Lasers,Lasers, Alexandrite,Lasers, Diode Pumped Solid State,Lasers, Er-YAG,Lasers, Erbium-Doped Yttrium Aluminum Garnet,Lasers, Ho-YAG,Lasers, Holmium Doped Yttrium Aluminum Garnet,Lasers, Nd-YAG,Lasers, Neodymium-Doped Yttrium Aluminum Garnet,Lasers, Ruby,Lasers, YAG,Lasers, Yttrium Aluminum Garnet,Lasers, Yttrium-Lithium-Fluoride,Potassium Titanyl Phosphate Lasers,Yttrium Aluminum Garnet Lasers,Er YAG Laser,Er YAG Lasers,Erbium Doped Yttrium Aluminum Garnet Lasers,Ho-YAG Laser,Ho-YAG Lasers,Holmium YAG Laser,Holmium YAG Lasers,Laser, Alexandrite,Laser, Er-YAG,Laser, Erbium YAG,Laser, Ho YAG,Laser, Ho-YAG,Laser, Holmium,Laser, Holmium-YAG,Laser, KTP,Laser, Nd YAG,Laser, Ruby,Laser, Solid-State,Laser, YAG,Laser, YLF,Laser, YSGG,Laser, Yttrium-Lithium-Fluoride,Laser, Yttrium-Scandium-Gallium Garnet,Lasers, Er YAG,Lasers, Erbium Doped Yttrium Aluminum Garnet,Lasers, Erbium YAG,Lasers, Ho YAG,Lasers, Holmium,Lasers, Holmium-YAG,Lasers, KTP,Lasers, Nd YAG,Lasers, Neodymium Doped Yttrium Aluminum Garnet,Lasers, Solid State,Lasers, YLF,Lasers, YSGG,Lasers, Yttrium Lithium Fluoride,Lasers, Yttrium-Scandium-Gallium Garnet,Nd YAG Laser,Nd YAG Lasers,Neodymium Doped Yttrium Aluminum Garnet Laser,Neodymium Doped Yttrium Aluminum Garnet Lasers,Solid State Laser,Solid-State Lasers,YAG Laser, Erbium,YAG Laser, Ho,YAG Lasers, Erbium,YAG Lasers, Ho,Yttrium Lithium Fluoride Laser,Yttrium Lithium Fluoride Lasers,Yttrium Scandium Gallium Garnet Laser,Yttrium Scandium Gallium Garnet Lasers
D028022 Low-Level Light Therapy Treatment using irradiation with light of low power intensity so that the effects are a response to the light and not due to heat. A variety of light sources, especially low-power lasers are used. LLLT,Laser Biostimulation,Laser Irradiation, Low-Power,Laser Therapy, Low-Level,Photobiomodulation,Laser Phototherapy,Laser Therapy, Low-Power,Low-Level Laser Therapy,Low-Power Laser Irradiation,Low-Power Laser Therapy,Photobiomodulation Therapy,Biostimulation, Laser,Irradiation, Low-Power Laser,Laser Irradiation, Low Power,Laser Therapies, Low-Level,Laser Therapies, Low-Power,Laser Therapy, Low Level,Laser Therapy, Low Power,Light Therapies, Low-Level,Light Therapy, Low-Level,Low Level Laser Therapy,Low Level Light Therapy,Low Power Laser Irradiation,Low Power Laser Therapy,Low-Level Laser Therapies,Low-Level Light Therapies,Low-Power Laser Therapies,Photobiomodulation Therapies,Photobiomodulations,Phototherapy, Laser,Therapies, Low-Level Light,Therapies, Photobiomodulation,Therapy, Low-Level Light,Therapy, Photobiomodulation

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