Biomaterial Database

[Changes in cholesterol level and binding in guinea pig tissues during ethanol intoxication and cholesterolemia]. 1988

G Kh Bozhko, and P V Voloshin, and V S Chursina

Content of cholesterol and binding of its labelled analogue was studied in guinea pigs tissues after hypercholesterolemia, ethanol intoxication and their combined action within 30, 60 and 90 days. Long-term consumption of cholesterol and chronic alcoholization caused accumulation of the steroid but in abundance of exogenous cholesterol its concentration was increased mainly in liver tissue and blood serum, whole in ethanol intoxication--in brain and kidney tissues. Chronic alcoholization contributed to cholesterosis development; the increase in cholesterol content was accompanied by a decrease in its renovation, especially distinct in liver and heart tissues. Combined effect of cholesterol and ethanol on liver tissue was detected within 60 days; at the same time, simultaneous effect of cholesterol and ethanol caused more pronounced impairments in liver tissue within 90 days as compared with the individual action of these drugs. Concentration of cholesterol was not altered in heart muscle after administration either cholesterol or ethanol, while its content was increased after the drugs simultaneous effect.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D002784	Cholesterol	The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.	Epicholesterol
D002791	Cholesterol, Dietary	Cholesterol present in food, especially in animal products.	Dietary Cholesterol
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000435	Alcoholic Intoxication	An acute brain syndrome which results from the excessive ingestion of ETHANOL or ALCOHOLIC BEVERAGES.	Drunkenness,Intoxication, Alcoholic,Drunkennesses
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001161	Arteriosclerosis	Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.	Arterioscleroses
D014018	Tissue Distribution	Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.	Distribution, Tissue,Distributions, Tissue,Tissue Distributions