Mitochondria in the Nuclei of Rat Myocardial Cells. 2020

Chupalav M Eldarov, and Irina M Vangely, and Valeriya B Vays, and Eugene V Sheval, and Susanne Holtze, and Thomas B Hildebrandt, and Natalia G Kolosova, and Vasily A Popkov, and Egor Y Plotnikov, and Dmitry B Zorov, and Lora E Bakeeva, and Vladimir P Skulachev
A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.

Electron microscopic study of cardiomyocytes taken from healthy Wistar and OXYS rats and naked mole rats (Heterocephalus glaber) revealed mitochondria in nuclei that lacked part of the nuclear envelope. The direct interaction of mitochondria with nucleoplasm is shown. The statistical analysis of the occurrence of mitochondria in cardiomyocyte nuclei showed that the percentage of nuclei with mitochondria was roughly around 1%, and did not show age and species dependency. Confocal microscopy of normal rat cardiac myocytes revealed a branched mitochondrial network in the vicinity of nuclei with an organization different than that of interfibrillar mitochondria. This mitochondrial network was energetically functional because it carried the membrane potential that responded by oscillatory mode after photodynamic challenge. We suggest that the presence of functional mitochondria in the nucleus is not only a consequence of certain pathologies but rather represents a normal biological phenomenon involved in mitochondrial/nuclear interactions.

UI MeSH Term Description Entries
D008854 Microscopy, Electron Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen. Electron Microscopy
D008929 Mitochondria, Heart The mitochondria of the myocardium. Heart Mitochondria,Myocardial Mitochondria,Mitochondrion, Heart,Heart Mitochondrion,Mitochondria, Myocardial
D009685 Nuclear Envelope The membrane system of the CELL NUCLEUS that surrounds the nucleoplasm. It consists of two concentric membranes separated by the perinuclear space. The structures of the envelope where it opens to the cytoplasm are called the nuclear pores (NUCLEAR PORE). Nuclear Membrane,Envelope, Nuclear,Envelopes, Nuclear,Membrane, Nuclear,Membranes, Nuclear,Nuclear Envelopes,Nuclear Membranes
D002467 Cell Nucleus Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) Cell Nuclei,Nuclei, Cell,Nucleus, Cell
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D018613 Microscopy, Confocal A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible. Confocal Microscopy,Confocal Microscopy, Scanning Laser,Laser Microscopy,Laser Scanning Confocal Microscopy,Laser Scanning Microscopy,Microscopy, Confocal, Laser Scanning,Confocal Laser Scanning Microscopy,Confocal Microscopies,Laser Microscopies,Laser Scanning Microscopies,Microscopies, Confocal,Microscopies, Laser,Microscopies, Laser Scanning,Microscopy, Laser,Microscopy, Laser Scanning,Scanning Microscopies, Laser,Scanning Microscopy, Laser
D019577 Mole Rats Any of several burrowing rodents of the families MURIDAE and Bathyergidae, found in eastern Europe, Africa, and Asia. They have short limbs, small eyes with permanently closed lids, and no tail. Three genera SPALAX (Muridae), Heterocephalus (Bathyergidae) and Cryptomys (Bathyergidae) are used frequently as experimental animals in biomedical research. (From Walker's Mammals of the World, 6th ed) Cryptomys,Heterocephalus,Mole-Rats,Molerats,Mole Rat,Mole-Rat,Molerat,Rat, Mole,Rats, Mole
D023421 Models, Animal Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing. Experimental Animal Models,Laboratory Animal Models,Animal Model,Animal Model, Experimental,Animal Model, Laboratory,Animal Models,Animal Models, Experimental,Animal Models, Laboratory,Experimental Animal Model,Laboratory Animal Model,Model, Animal,Model, Experimental Animal,Model, Laboratory Animal,Models, Experimental Animal,Models, Laboratory Animal

Related Publications

Chupalav M Eldarov, and Irina M Vangely, and Valeriya B Vays, and Eugene V Sheval, and Susanne Holtze, and Thomas B Hildebrandt, and Natalia G Kolosova, and Vasily A Popkov, and Egor Y Plotnikov, and Dmitry B Zorov, and Lora E Bakeeva, and Vladimir P Skulachev
July 1976, Virchows Archiv. B, Cell pathology,
Chupalav M Eldarov, and Irina M Vangely, and Valeriya B Vays, and Eugene V Sheval, and Susanne Holtze, and Thomas B Hildebrandt, and Natalia G Kolosova, and Vasily A Popkov, and Egor Y Plotnikov, and Dmitry B Zorov, and Lora E Bakeeva, and Vladimir P Skulachev
July 1973, Journal of ultrastructure research,
Chupalav M Eldarov, and Irina M Vangely, and Valeriya B Vays, and Eugene V Sheval, and Susanne Holtze, and Thomas B Hildebrandt, and Natalia G Kolosova, and Vasily A Popkov, and Egor Y Plotnikov, and Dmitry B Zorov, and Lora E Bakeeva, and Vladimir P Skulachev
October 1994, The Plant cell,
Chupalav M Eldarov, and Irina M Vangely, and Valeriya B Vays, and Eugene V Sheval, and Susanne Holtze, and Thomas B Hildebrandt, and Natalia G Kolosova, and Vasily A Popkov, and Egor Y Plotnikov, and Dmitry B Zorov, and Lora E Bakeeva, and Vladimir P Skulachev
March 1971, The Journal of cell biology,
Chupalav M Eldarov, and Irina M Vangely, and Valeriya B Vays, and Eugene V Sheval, and Susanne Holtze, and Thomas B Hildebrandt, and Natalia G Kolosova, and Vasily A Popkov, and Egor Y Plotnikov, and Dmitry B Zorov, and Lora E Bakeeva, and Vladimir P Skulachev
May 2000, Journal of cardiovascular pharmacology,
Chupalav M Eldarov, and Irina M Vangely, and Valeriya B Vays, and Eugene V Sheval, and Susanne Holtze, and Thomas B Hildebrandt, and Natalia G Kolosova, and Vasily A Popkov, and Egor Y Plotnikov, and Dmitry B Zorov, and Lora E Bakeeva, and Vladimir P Skulachev
January 1971, Virchows Archiv. B, Cell pathology,
Chupalav M Eldarov, and Irina M Vangely, and Valeriya B Vays, and Eugene V Sheval, and Susanne Holtze, and Thomas B Hildebrandt, and Natalia G Kolosova, and Vasily A Popkov, and Egor Y Plotnikov, and Dmitry B Zorov, and Lora E Bakeeva, and Vladimir P Skulachev
May 1968, Experimental cell research,
Chupalav M Eldarov, and Irina M Vangely, and Valeriya B Vays, and Eugene V Sheval, and Susanne Holtze, and Thomas B Hildebrandt, and Natalia G Kolosova, and Vasily A Popkov, and Egor Y Plotnikov, and Dmitry B Zorov, and Lora E Bakeeva, and Vladimir P Skulachev
January 1974, Biochimie,
Chupalav M Eldarov, and Irina M Vangely, and Valeriya B Vays, and Eugene V Sheval, and Susanne Holtze, and Thomas B Hildebrandt, and Natalia G Kolosova, and Vasily A Popkov, and Egor Y Plotnikov, and Dmitry B Zorov, and Lora E Bakeeva, and Vladimir P Skulachev
January 1972, Virchows Archiv. B, Cell pathology,
Chupalav M Eldarov, and Irina M Vangely, and Valeriya B Vays, and Eugene V Sheval, and Susanne Holtze, and Thomas B Hildebrandt, and Natalia G Kolosova, and Vasily A Popkov, and Egor Y Plotnikov, and Dmitry B Zorov, and Lora E Bakeeva, and Vladimir P Skulachev
October 1970, Journal of cellular physiology,
Copied contents to your clipboard!