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The absorption, distribution and excretion of (+/-)-(R*)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarb oxylic acid (R*)-1-benzyl-3-piperidinyl ester, methyl ester hydrochloride (benidipine hydrochloride, KW-3049) were studied after repeated doses to rats. The results were summarized as follows: 1. After oral repeated administration once a day for 3 weeks, the radioactivities in blood and tissues increased up to the 14th day, and thereafter they tended to show the steady state. 2. The radioactivity in the tissues at 1 h after last dosing was compared with that at 1 h after single administration. Both tissue distribution patterns were not markedly different, but the concentrations in the liver, testicles, skin and descending aorta significantly increased, showing approximately the 2-fold radioactivities. 3. The radioactivities were excreted in the urine (6%) and feces (88%). The excretion of radioactivity in urine and feces did not change markedly during the repeated administration period.
H Kobayashi, and
T Ohishi, and
H Nishiie, and
S Kobayashi, and
A Inoue, and
T Oka, and
N Nakamizo
June 1997,
Xenobiotica; the fate of foreign compounds in biological systems,
H Kobayashi, and
T Ohishi, and
H Nishiie, and
S Kobayashi, and
A Inoue, and
T Oka, and
N Nakamizo
April 1994,
Arzneimittel-Forschung,
H Kobayashi, and
T Ohishi, and
H Nishiie, and
S Kobayashi, and
A Inoue, and
T Oka, and
N Nakamizo
January 1997,
Methods and findings in experimental and clinical pharmacology,
H Kobayashi, and
T Ohishi, and
H Nishiie, and
S Kobayashi, and
A Inoue, and
T Oka, and
N Nakamizo
October 1993,
Arzneimittel-Forschung,
H Kobayashi, and
T Ohishi, and
H Nishiie, and
S Kobayashi, and
A Inoue, and
T Oka, and
N Nakamizo
January 2022,
Xenobiotica; the fate of foreign compounds in biological systems,
H Kobayashi, and
T Ohishi, and
H Nishiie, and
S Kobayashi, and
A Inoue, and
T Oka, and
N Nakamizo
February 1998,
Xenobiotica; the fate of foreign compounds in biological systems,
H Kobayashi, and
T Ohishi, and
H Nishiie, and
S Kobayashi, and
A Inoue, and
T Oka, and
N Nakamizo
January 2004,
Arzneimittel-Forschung,
H Kobayashi, and
T Ohishi, and
H Nishiie, and
S Kobayashi, and
A Inoue, and
T Oka, and
N Nakamizo
January 1977,
Journal of pharmaceutical sciences,
H Kobayashi, and
T Ohishi, and
H Nishiie, and
S Kobayashi, and
A Inoue, and
T Oka, and
N Nakamizo
April 1994,
Arzneimittel-Forschung,
H Kobayashi, and
T Ohishi, and
H Nishiie, and
S Kobayashi, and
A Inoue, and
T Oka, and
N Nakamizo
April 1985,
The Japanese journal of antibiotics,
