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Two derivatives of biosynthetic human growth hormone, a sulfoxide and a mixture of two monodesamido isomers, have been isolated and characterized. The sulfoxide derivative arises from an oxidation of Met-14. The major site of deamidation is at Asn-149 with a minor site at Asn-152. In addition, a fraction has been isolated from a sample of human growth hormone that was maintained at 40 degrees C for 2 weeks. This fraction, the isolated impurities fraction, contains the sulfoxide and the desamido forms, thereby demonstrating that these derivatives are the primary degradation products of biosynthetic human growth hormone. The sulfoxide, the desamido, and the isolated impurities fraction exhibit full biological activity.
G W Becker, and
P M Tackitt, and
W W Bromer, and
D S Lefeber, and
R M Riggin
June 1994,
Pharmacology & toxicology,
G W Becker, and
P M Tackitt, and
W W Bromer, and
D S Lefeber, and
R M Riggin
January 1994,
European journal of biochemistry,
G W Becker, and
P M Tackitt, and
W W Bromer, and
D S Lefeber, and
R M Riggin
July 1987,
The Medical letter on drugs and therapeutics,
G W Becker, and
P M Tackitt, and
W W Bromer, and
D S Lefeber, and
R M Riggin
September 1986,
International journal of peptide and protein research,
G W Becker, and
P M Tackitt, and
W W Bromer, and
D S Lefeber, and
R M Riggin
January 1987,
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G W Becker, and
P M Tackitt, and
W W Bromer, and
D S Lefeber, and
R M Riggin
July 1991,
The Journal of biological chemistry,
G W Becker, and
P M Tackitt, and
W W Bromer, and
D S Lefeber, and
R M Riggin
January 1990,
Acta paediatrica Scandinavica. Supplement,
G W Becker, and
P M Tackitt, and
W W Bromer, and
D S Lefeber, and
R M Riggin
January 1987,
International journal of peptide and protein research,
G W Becker, and
P M Tackitt, and
W W Bromer, and
D S Lefeber, and
R M Riggin
March 1981,
International journal of peptide and protein research,
G W Becker, and
P M Tackitt, and
W W Bromer, and
D S Lefeber, and
R M Riggin
December 1985,
The Medical letter on drugs and therapeutics,
