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Expression of human angiogenin in cultured baby hamster kidney cells. 1988
K Kurachi, and
S M Rybak, and
J W Fett, and
R Shapiro, and
D J Strydom, and
K A Olson, and
J F Riordan, and
E W Davie, and
B L Vallee
Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Boston, Massachusetts 02115.
Baby hamster kidney cells were transformed with DNA sequences derived from the gene for human angiogenin. Expression was under the transcriptional control of the inducible mouse metallothionein 1 promoter. Recombinant angiogenin was purified and shown to be chemically, biologically, and enzymatically indistinguishable from the natural product. The large-scale production of recombinant angiogenin achieved should facilitate detailed studies into the structure-function relationships of this potent angiogenic molecule.
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D J Strydom, and
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E W Davie, and
B L Vallee
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