Biomaterial Database

Direct effects of cholecystokinin on human gastric motility. 1988

F E Lüdtke, and K Golenhofen, and C Köhne

Department of General Surgery, University of Göttingen.

For a precise analysis of the cholecystokinin (CCK 8) effects on human stomach, we dissected strips of longitudinal and circular muscle from the fundus, corpus and antrum, and circular muscle from the inner and outer pyloric sphincter and duodenum. Specimens were taken during gastrectomy and from stomachs of kidney donors. Mechanical activity was simultaneously recorded under auxotonic conditions. After CCK 8 application, the following effects were observed: (1) direct excitatory effects of CCK 8 with great regional variations in quality and intensity; (2) increases in amplitude of phasic contractions in the outer plyorus and longitudinal antrum (in the other types of preparations the effects were negligible; (3) increases in tonic activity in preparations of the proximal stomach and in strips of longitudinal muscle form the antrum, and (4) remarkable interindividual differences, with negligible responses in one third of the 24 human stomachs examined.

UI	MeSH Term	Description	Entries
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005746	Gastric Emptying	The evacuation of food from the stomach into the duodenum.	Emptying, Gastric,Emptyings, Gastric,Gastric Emptyings
D005769	Gastrointestinal Motility	The motor activity of the GASTROINTESTINAL TRACT.	Intestinal Motility,Gastrointestinal Motilities,Intestinal Motilities,Motilities, Gastrointestinal,Motilities, Intestinal,Motility, Gastrointestinal,Motility, Intestinal
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000109	Acetylcholine	A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.	2-(Acetyloxy)-N,N,N-trimethylethanaminium,Acetilcolina Cusi,Acetylcholine Bromide,Acetylcholine Chloride,Acetylcholine Fluoride,Acetylcholine Hydroxide,Acetylcholine Iodide,Acetylcholine L-Tartrate,Acetylcholine Perchlorate,Acetylcholine Picrate,Acetylcholine Picrate (1:1),Acetylcholine Sulfate (1:1),Bromoacetylcholine,Chloroacetylcholine,Miochol,Acetylcholine L Tartrate,Bromide, Acetylcholine,Cusi, Acetilcolina,Fluoride, Acetylcholine,Hydroxide, Acetylcholine,Iodide, Acetylcholine,L-Tartrate, Acetylcholine,Perchlorate, Acetylcholine
D012844	Sincalide	An octapeptide hormone present in the intestine and brain. When secreted from the gastric mucosa, it stimulates the release of bile from the gallbladder and digestive enzymes from the pancreas.	CCK-8,Cholecystokinin Octapeptide,CCK-OP,Cholecystokinin Pancreozymin C-Terminal Octapeptide,H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2,Kinevac,OP-CCK,SQ-19,844,SQ-19844,Syncalide,Cholecystokinin Pancreozymin C Terminal Octapeptide,SQ 19,844,SQ 19844,SQ19,844,SQ19844
D013270	Stomach	An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.	Stomachs
D046508	Culture Techniques	Methods of maintaining or growing biological materials in controlled laboratory conditions. These include the cultures of CELLS; TISSUES; organs; or embryo in vitro. Both animal and plant tissues may be cultured by a variety of methods. Cultures may derive from normal or abnormal tissues, and consist of a single cell type or mixed cell types.	Culture Technique,Technique, Culture,Techniques, Culture