-transparent.png){kind=logo}
The therapeutic effects of sucralfate on ulcerated gastric and duodenal mucosa is well known. There is, however, very little information about its effect on the mucosa of the small intestine. We studied the possible protective effect of sucralfate against indomethacin-induced intestinal ulceration in the rat. Sucralfate was found to possess a marked protective effect on the intestinal mucosa (ulcer index 23.16 +/- 6.58 vs. 225 +/- 36.37; p less than 0.001). Sucralfate elevated basal mucosal prostaglandin E2 generation (p less than 0.001), and partially overcame the inhibition of prostaglandin E2 synthesis caused by indomethacin (p less than 0.03), but had no effect on mucosal cAMP level. The effect of sucralfate on prostaglandin E2 content might partially explain its protective effect on the intestinal mucosa.
Y Waisman, and
I Zahavi, and
H Marcus, and
M Ligumsky, and
Y Rosenbach, and
G Dinari
May 1996,
Israel journal of medical sciences,
Y Waisman, and
I Zahavi, and
H Marcus, and
M Ligumsky, and
Y Rosenbach, and
G Dinari
August 1995,
Journal of pediatric gastroenterology and nutrition,
Y Waisman, and
I Zahavi, and
H Marcus, and
M Ligumsky, and
Y Rosenbach, and
G Dinari
July 1985,
Pathology,
Y Waisman, and
I Zahavi, and
H Marcus, and
M Ligumsky, and
Y Rosenbach, and
G Dinari
January 1992,
Life sciences,
Y Waisman, and
I Zahavi, and
H Marcus, and
M Ligumsky, and
Y Rosenbach, and
G Dinari
November 1980,
Digestive diseases and sciences,
Y Waisman, and
I Zahavi, and
H Marcus, and
M Ligumsky, and
Y Rosenbach, and
G Dinari
January 2000,
Digestion,
Y Waisman, and
I Zahavi, and
H Marcus, and
M Ligumsky, and
Y Rosenbach, and
G Dinari
March 1988,
Biochemistry international,
Y Waisman, and
I Zahavi, and
H Marcus, and
M Ligumsky, and
Y Rosenbach, and
G Dinari
February 1991,
Alimentary pharmacology & therapeutics,
Y Waisman, and
I Zahavi, and
H Marcus, and
M Ligumsky, and
Y Rosenbach, and
G Dinari
March 2023,
The Journal of pharmacy and pharmacology,
Y Waisman, and
I Zahavi, and
H Marcus, and
M Ligumsky, and
Y Rosenbach, and
G Dinari
October 2003,
International journal of experimental pathology,
