Acute release of catecholamines on circulating blood cell adrenoceptors and metabolic indices in dog. 1988

P Valet, and C Damase-Michel, and M Taouis, and J L Montastruc, and J Cotonat, and P Montastruc
Laboratoire de Pharmacologie Médicale et Clinique, INSERM U 317, Faculté de Médecine, Toulouse, France.

The effects of acute release of endogenous catecholamines on both platelet alpha 2 and leukocyte beta adrenoreceptors and metabolic indices (glucose and free fatty acids) were investigated in dogs by means of a model of neurogenic hypertension following acute sinoaortic denervation (ASAD). Despite the marked increase in catecholamine levels (+4.2-fold for noradrenaline and 16.7-fold for adrenaline, for example, at minute 45 following ASAD) and in glucose plasma levels, and the significant decrease in free fatty acid plasma levels, no change in platelet alpha 2 or leukocyte beta adrenoreceptor binding sites (number as well as affinity) was observed during the whole experiment. It is suggested that the number of platelet alpha 2- and leukocyte beta-adrenoreceptors is not submitted to short-term regulation, at least by endogenous catecholamines in dogs.

UI MeSH Term Description Entries
D007962 Leukocytes White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES). Blood Cells, White,Blood Corpuscles, White,White Blood Cells,White Blood Corpuscles,Blood Cell, White,Blood Corpuscle, White,Corpuscle, White Blood,Corpuscles, White Blood,Leukocyte,White Blood Cell,White Blood Corpuscle
D008297 Male Males
D010869 Pindolol A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638) Prindolol,LB-46,Visken,LB 46,LB46
D011941 Receptors, Adrenergic Cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. Adrenergic receptors may also be classified according to the subtypes of G-proteins with which they bind; this scheme does not respect the alpha-beta distinction. Adrenergic Receptors,Adrenoceptor,Adrenoceptors,Norepinephrine Receptor,Receptors, Epinephrine,Receptors, Norepinephrine,Adrenergic Receptor,Epinephrine Receptors,Norepinephrine Receptors,Receptor, Adrenergic,Receptor, Norepinephrine
D001773 Blood Cells The cells found in the body fluid circulating throughout the CARDIOVASCULAR SYSTEM. Blood Corpuscles,Blood Cell,Blood Corpuscle,Cell, Blood,Cells, Blood,Corpuscle, Blood,Corpuscles, Blood
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D001792 Blood Platelets Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation. Platelets,Thrombocytes,Blood Platelet,Platelet,Platelet, Blood,Platelets, Blood,Thrombocyte
D002395 Catecholamines A general class of ortho-dihydroxyphenylalkylamines derived from TYROSINE. Catecholamine,Sympathin,Sympathins
D002462 Cell Membrane The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells. Plasma Membrane,Cytoplasmic Membrane,Cell Membranes,Cytoplasmic Membranes,Membrane, Cell,Membrane, Cytoplasmic,Membrane, Plasma,Membranes, Cell,Membranes, Cytoplasmic,Membranes, Plasma,Plasma Membranes
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog

Related Publications

P Valet, and C Damase-Michel, and M Taouis, and J L Montastruc, and J Cotonat, and P Montastruc
January 1988, Naunyn-Schmiedeberg's archives of pharmacology,
P Valet, and C Damase-Michel, and M Taouis, and J L Montastruc, and J Cotonat, and P Montastruc
July 1987, Clinical nephrology,
P Valet, and C Damase-Michel, and M Taouis, and J L Montastruc, and J Cotonat, and P Montastruc
April 1989, The Journal of pharmacology and experimental therapeutics,
P Valet, and C Damase-Michel, and M Taouis, and J L Montastruc, and J Cotonat, and P Montastruc
April 1987, Canadian journal of physiology and pharmacology,
P Valet, and C Damase-Michel, and M Taouis, and J L Montastruc, and J Cotonat, and P Montastruc
January 1985, British medical journal (Clinical research ed.),
P Valet, and C Damase-Michel, and M Taouis, and J L Montastruc, and J Cotonat, and P Montastruc
December 1966, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
P Valet, and C Damase-Michel, and M Taouis, and J L Montastruc, and J Cotonat, and P Montastruc
January 1985, Patologicheskaia fiziologiia i eksperimental'naia terapiia,
P Valet, and C Damase-Michel, and M Taouis, and J L Montastruc, and J Cotonat, and P Montastruc
March 1996, Diabetes care,
P Valet, and C Damase-Michel, and M Taouis, and J L Montastruc, and J Cotonat, and P Montastruc
July 1993, The Journal of pharmacology and experimental therapeutics,
P Valet, and C Damase-Michel, and M Taouis, and J L Montastruc, and J Cotonat, and P Montastruc
January 1980, Laboratornoe delo,
Copied contents to your clipboard!