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Decreased bone density has been reported in women with hyperprolactinaemia due to pituitary tumours. We identified a number of seemingly healthy women with hyperprolactinaemia, i.e. a serum prolactin concentration exceeding 500 mU/l (25 micrograms/l) on three occasions, during a study in 1980/1981 of a representative population sample of greater than 1,400 women in seven different age strata (range 26-72 years). We compared vertebral bone mineral content and bone mineral areal content in 5 hyperprolactinaemic normally menstruating 50-year-old women with that of 6 controls matched for age and menstrual status but found no difference. Since the degree of prolactin elevation was similar in our study group to that previously reported for hyperprolactinaemic subjects with pituitary tumours and the time of exposure to raised hormone concentration appears to be of the same magnitude, other hormonal changes than hyperprolactinaemia per se seem to be the cause of low bone mineral content in women with hyperprolactinaemia and amenorrhoea.
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May 1989,
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August 2015,
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego,
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October 1990,
Medicine and science in sports and exercise,
E Nyström, and
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G Lindstedt
January 1980,
Acta medica Scandinavica,
E Nyström, and
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G Lindstedt
July 1994,
The American journal of cardiology,
E Nyström, and
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February 1997,
Indian journal of medical sciences,
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G Lindstedt
January 1987,
British medical journal (Clinical research ed.),
E Nyström, and
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G Rybo, and
G Lindstedt
May 1980,
Acta endocrinologica,
