Inhibitory Effects of Cypermethrin on Interactions of the Androgen Receptor with Coactivators ARA70 and ARA55. 2020

Zhen Ding, and Jun Yu Shen, and Jia Wei Hong, and Rui Zhang, and Zheng Li, and Qi Wang, and Jin Peng Zhang, and Mei Rong Zhang, and Li Chun Xu
School of Public Health, Xuzhou Medical University, Xuzhou 221000, Jiangsu, China.

OBJECTIVE The purpose of this study was to investigate the anti-androgenic mechanism of cypermethrin involving coactivators. METHODS Mammalian two-hybrid assays were performed to study the effects of cypermethrin on interactions of the androgen receptor (AR) with the coactivators androgen receptor-associated protein 70 (ARA70) and androgen receptor-associated protein 55 (ARA55). RESULTS The results showed that AR-ARA70 and AR-ARA55 interactions were remarkably enhanced by dihydrotestosterone (DHT, P ≤ 0.05). Cypermethrin inhibited DHT-induced AR-ARA70 and AR-ARA55 interactions significantly ( P ≤ 0.05). CONCLUSIONS The study indicates that cypermethrin exhibits inhibitory effects on AR transcription associated with repression of AR-ARA70 and AR-ARA55 interactions in a ligand-dependent manner. The data show novel anti-androgenic mechanisms of cypermethrin that contribute to male reproductive toxicology.

UI MeSH Term Description Entries
D007306 Insecticides Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics. Insecticide
D011722 Pyrethrins The active insecticidal constituent of CHRYSANTHEMUM CINERARIIFOLIUM flowers. Pyrethrin I is the pyretholone ester of chrysanthemummonocarboxylic acid and pyrethrin II is the pyretholone ester of chrysanthemumdicarboxylic acid monomethyl ester. Pyrethrin,Pyrethroid,Pyrethroids
D011944 Receptors, Androgen Proteins, generally found in the CYTOPLASM, that specifically bind ANDROGENS and mediate their cellular actions. The complex of the androgen and receptor migrates to the CELL NUCLEUS where it induces transcription of specific segments of DNA. Androgen Receptors,5 alpha-Dihydrotestosterone Receptor,Androgen Receptor,Dihydrotestosterone Receptors,Receptor, Testosterone,Receptors, Androgens,Receptors, Dihydrotestosterone,Receptors, Stanolone,Stanolone Receptor,Testosterone Receptor,5 alpha Dihydrotestosterone Receptor,Androgens Receptors,Receptor, 5 alpha-Dihydrotestosterone,Receptor, Androgen,Receptor, Stanolone,Stanolone Receptors,alpha-Dihydrotestosterone Receptor, 5
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D002522 Chlorocebus aethiops A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research. African Green Monkey,Cercopithecus aethiops,Cercopithecus griseoviridis,Cercopithecus griseus,Cercopithecus pygerythrus,Cercopithecus sabeus,Cercopithecus tantalus,Chlorocebus cynosuros,Chlorocebus cynosurus,Chlorocebus pygerythrus,Green Monkey,Grivet Monkey,Lasiopyga weidholzi,Malbrouck,Malbrouck Monkey,Monkey, African Green,Monkey, Green,Monkey, Grivet,Monkey, Vervet,Savanah Monkey,Vervet Monkey,Savannah Monkey,African Green Monkey,Chlorocebus cynosuro,Green Monkey, African,Green Monkeys,Grivet Monkeys,Malbrouck Monkeys,Malbroucks,Monkey, Malbrouck,Monkey, Savanah,Monkey, Savannah,Savannah Monkeys,Vervet Monkeys
D000726 Androgen Antagonists Compounds which inhibit or antagonize the biosynthesis or actions of androgens. Androgen Antagonist,Antiandrogen,Antiandrogens,Anti-Androgen Effect,Anti-Androgen Effects,Antiandrogen Effect,Antiandrogen Effects,Antagonist, Androgen,Antagonists, Androgen,Anti Androgen Effect,Anti Androgen Effects,Effect, Anti-Androgen,Effect, Antiandrogen,Effects, Anti-Androgen,Effects, Antiandrogen
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D047908 Intracellular Signaling Peptides and Proteins Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors. Intracellular Signaling Peptides,Intracellular Signaling Proteins,Peptides, Intracellular Signaling,Proteins, Intracellular Signaling,Signaling Peptides, Intracellular,Signaling Proteins, Intracellular
D056918 Nuclear Receptor Coactivators Proteins that enhance gene expression when associated with ligand bound activated NUCLEAR RECEPTORS. The coactivators may act through an enzymatic process that affects the rate of transcription or the structure of chromatin. Alternatively nuclear receptor coactivators can function as adaptor proteins that bring nuclear receptors into close proximity with transcriptional complexes.
D059002 Androgen Receptor Antagonists Compounds that bind to and inhibit the activation of ANDROGEN RECEPTORS. Androgen Receptor Antagonist,Antagonist, Androgen Receptor,Antagonists, Androgen Receptor,Receptor Antagonist, Androgen,Receptor Antagonists, Androgen

Related Publications

Zhen Ding, and Jun Yu Shen, and Jia Wei Hong, and Rui Zhang, and Zheng Li, and Qi Wang, and Jin Peng Zhang, and Mei Rong Zhang, and Li Chun Xu
September 2013, Toxicology,
Zhen Ding, and Jun Yu Shen, and Jia Wei Hong, and Rui Zhang, and Zheng Li, and Qi Wang, and Jin Peng Zhang, and Mei Rong Zhang, and Li Chun Xu
February 2012, Toxicology,
Zhen Ding, and Jun Yu Shen, and Jia Wei Hong, and Rui Zhang, and Zheng Li, and Qi Wang, and Jin Peng Zhang, and Mei Rong Zhang, and Li Chun Xu
July 2013, Journal of applied toxicology : JAT,
Zhen Ding, and Jun Yu Shen, and Jia Wei Hong, and Rui Zhang, and Zheng Li, and Qi Wang, and Jin Peng Zhang, and Mei Rong Zhang, and Li Chun Xu
January 2008, Advances in experimental medicine and biology,
Zhen Ding, and Jun Yu Shen, and Jia Wei Hong, and Rui Zhang, and Zheng Li, and Qi Wang, and Jin Peng Zhang, and Mei Rong Zhang, and Li Chun Xu
July 2015, Environmental toxicology and pharmacology,
Zhen Ding, and Jun Yu Shen, and Jia Wei Hong, and Rui Zhang, and Zheng Li, and Qi Wang, and Jin Peng Zhang, and Mei Rong Zhang, and Li Chun Xu
September 2012, Toxicology,
Zhen Ding, and Jun Yu Shen, and Jia Wei Hong, and Rui Zhang, and Zheng Li, and Qi Wang, and Jin Peng Zhang, and Mei Rong Zhang, and Li Chun Xu
March 1999, The Journal of biological chemistry,
Zhen Ding, and Jun Yu Shen, and Jia Wei Hong, and Rui Zhang, and Zheng Li, and Qi Wang, and Jin Peng Zhang, and Mei Rong Zhang, and Li Chun Xu
September 2005, Journal of cutaneous pathology,
Zhen Ding, and Jun Yu Shen, and Jia Wei Hong, and Rui Zhang, and Zheng Li, and Qi Wang, and Jin Peng Zhang, and Mei Rong Zhang, and Li Chun Xu
June 1999, The Keio journal of medicine,
Zhen Ding, and Jun Yu Shen, and Jia Wei Hong, and Rui Zhang, and Zheng Li, and Qi Wang, and Jin Peng Zhang, and Mei Rong Zhang, and Li Chun Xu
April 2003, Proceedings of the National Academy of Sciences of the United States of America,
Copied contents to your clipboard!