BIOMAT Database Logo BIOMAT Database Logo

Homology among acid proteases: comparison of crystal structures at 3A resolution of acid proteases from Rhizopus chinensis and Endothia parasitica. 1977

E Subramanian, and I D Swan, and M Liu, and D R Davies, and J A Jenkins, and I J Tickle, and T L Blundell

The molecular structures of two fungal acid proteases at 3 A resolution have been compared, and found to have similar secondary and tertiary folding. These enzymes are bilobal and have a pronounced cleft between the two lobes. This cleft has been identified as the active site region from inhibitor binding studies. The results of the comparison are discussed in terms of homology among the acid proteases in general.

UI MeSH Term Description Entries
D008628 Mercury A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.
D008961 Models, Structural A representation, generally small in scale, to show the structure, construction, or appearance of something. (From Random House Unabridged Dictionary, 2d ed) Model, Structural,Structural Model,Structural Models
D010434 Pepsin A Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain and is inhibited by methyl 2-diaazoacetamidohexanoate. It cleaves peptides preferentially at the carbonyl linkages of phenylalanine or leucine and acts as the principal digestive enzyme of gastric juice. Pepsin,Pepsin 1,Pepsin 3
D010447 Peptide Hydrolases Hydrolases that specifically cleave the peptide bonds found in PROTEINS and PEPTIDES. Examples of sub-subclasses for this group include EXOPEPTIDASES and ENDOPEPTIDASES. Peptidase,Peptidases,Peptide Hydrolase,Protease,Proteases,Proteinase,Proteinases,Proteolytic Enzyme,Proteolytic Enzymes,Esteroproteases,Enzyme, Proteolytic,Hydrolase, Peptide
D010984 Platinum A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae". Platinum Black
D011485 Protein Binding The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments. Plasma Protein Binding Capacity,Binding, Protein
D011487 Protein Conformation The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain). Conformation, Protein,Conformations, Protein,Protein Conformations
D006046 Gold A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.
D001203 Ascomycota A phylum of fungi which have cross-walls or septa in the mycelium. The perfect state is characterized by the formation of a saclike cell (ascus) containing ascospores. Most pathogenic fungi with a known perfect state belong to this phylum. Ascomycetes,Cochliobolus,Sclerotinia,Ascomycete,Ascomycotas,Sclerotinias
D001665 Binding Sites The parts of a macromolecule that directly participate in its specific combination with another molecule. Combining Site,Binding Site,Combining Sites,Site, Binding,Site, Combining,Sites, Binding,Sites, Combining

Related Publications

E Subramanian, and I D Swan, and M Liu, and D R Davies, and J A Jenkins, and I J Tickle, and T L Blundell
The structure at 0.3nm (3A) resolution of the acid proteinase from Endothia parasitica [proceedings].
January 1977, Biochemical Society transactions,
E Subramanian, and I D Swan, and M Liu, and D R Davies, and J A Jenkins, and I J Tickle, and T L Blundell
Structure of acid protease from Endothia parasitica in cross-linked form at 2.45-A resolution.
April 1979, Biochemistry,
E Subramanian, and I D Swan, and M Liu, and D R Davies, and J A Jenkins, and I J Tickle, and T L Blundell
The low resolution structure analysis of an acid proteinase from Endothia parasitica.
December 1975, Journal of molecular biology,
E Subramanian, and I D Swan, and M Liu, and D R Davies, and J A Jenkins, and I J Tickle, and T L Blundell
The structure of acid protease from Endothia parasitica in cross-linked form at 3.5 A resolution.
February 1978, Biochemical and biophysical research communications,
E Subramanian, and I D Swan, and M Liu, and D R Davies, and J A Jenkins, and I J Tickle, and T L Blundell
N-terminal amino acid sequences of acid proteases: acid proteases from Penicillium roqueforti and Rhizopus chinensis and alignment with penicillopepsin and mammalian proteases.
May 1977, Canadian journal of biochemistry,
E Subramanian, and I D Swan, and M Liu, and D R Davies, and J A Jenkins, and I J Tickle, and T L Blundell
Intermolecular cross-linking of a protein crystal--acid protease from Endothia parasitica--in 2.7 M ammonium sulfate solution.
February 1978, Biochemical and biophysical research communications,
E Subramanian, and I D Swan, and M Liu, and D R Davies, and J A Jenkins, and I J Tickle, and T L Blundell
Structure and refinement at 1.8 A resolution of the aspartic proteinase from Rhizopus chinensis.
August 1987, Journal of molecular biology,
E Subramanian, and I D Swan, and M Liu, and D R Davies, and J A Jenkins, and I J Tickle, and T L Blundell
Comparison of homology models and crystal structures of cuticle-degrading proteases from nematophagous fungi: structural basis of nematicidal activity.
June 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
E Subramanian, and I D Swan, and M Liu, and D R Davies, and J A Jenkins, and I J Tickle, and T L Blundell
A structural comparison of 21 inhibitor complexes of the aspartic proteinase from Endothia parasitica.
November 1994, Protein science : a publication of the Protein Society,
E Subramanian, and I D Swan, and M Liu, and D R Davies, and J A Jenkins, and I J Tickle, and T L Blundell
X-ray analysis and circular dichroism of the acid protease from Endothia parasitica and chymosin.
January 1977, Advances in experimental medicine and biology,
Copied contents to your clipboard!