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Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents. 2014
Kiran Gangarapu, and
Sarangapani Manda, and
Anvesh Jallapally, and
Sreekanth Thota, and
Subhas S Karki, and
Jan Balzarini, and
Erik De Clercq, and
Harukuni Tokuda
Department of Pharmaceutical Chemistry, Kakatiya Institute of Pharmaceutical Sciences, Pembarthy (V), Hasanparthy (M), Warangal, 506 371 AP India.
A series of new β-isatin aldehyde-N,N'-thiocarbohydrazone, bis-β-isatin thiocarbohydrazones, bis-β-isatin carbohydrazones was synthesized by condensation of 5-substituted isatin with thiocarbohydrazide or carbohydrazide. The chemical structures of the newly synthesized compounds were confirmed by FT-IR, 1H NMR, and mass spectral analysis. The synthesized compounds were evaluated for in vitro antiviral activity against various strains of DNA and RNA viruses, but exhibited moderate antiviral activity compared with the reference compounds. Among all the compounds 6c exhibited the highest chemoprevention activity in a two-stage mouse-skin carcinogenesis test.
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