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The comparative efficacy of imipenem-cilastatin versus clindamycin and gentamicin in the treatment of polymicrobial infections was evaluated. Eleven patients completed treatment with the former and nine with the latter. Conditions treated included infected extremity ulcers, peritonitis, perirectal abscess, soft-tissue abscess, abdominal abscess, and acute diverticulitis. Similar rates of bacteriologic and clinical cure or improvement were achieved with the two treatments. Superinfection occurred in two patients who received imipenem-cilastatin and one who received clindamycin and gentamicin. No significant difference in adverse effects was noted. Imipenem-cilastatin appears to be an effective antibiotic in treating polymicrobial infections; however, a much larger patient population would be required to detect a significant difference in the efficacy rates or frequency of adverse effects when comparing the two regimens.
L H Danziger, and
R J Creger, and
J A Shwed, and
T A Stellato, and
T Hau
June 1985,
The American journal of medicine,
L H Danziger, and
R J Creger, and
J A Shwed, and
T A Stellato, and
T Hau
January 1987,
Scandinavian journal of infectious diseases. Supplementum,
L H Danziger, and
R J Creger, and
J A Shwed, and
T A Stellato, and
T Hau
January 1993,
Drugs under experimental and clinical research,
L H Danziger, and
R J Creger, and
J A Shwed, and
T A Stellato, and
T Hau
January 1986,
Scandinavian journal of infectious diseases,
L H Danziger, and
R J Creger, and
J A Shwed, and
T A Stellato, and
T Hau
January 1992,
Clinical therapeutics,
L H Danziger, and
R J Creger, and
J A Shwed, and
T A Stellato, and
T Hau
September 1993,
The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses,
L H Danziger, and
R J Creger, and
J A Shwed, and
T A Stellato, and
T Hau
April 1984,
Lancet (London, England),
L H Danziger, and
R J Creger, and
J A Shwed, and
T A Stellato, and
T Hau
August 1992,
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
L H Danziger, and
R J Creger, and
J A Shwed, and
T A Stellato, and
T Hau
January 1985,
Reviews of infectious diseases,
L H Danziger, and
R J Creger, and
J A Shwed, and
T A Stellato, and
T Hau
March 1988,
Archives of surgery (Chicago, Ill. : 1960),
