[Network pharmacological study of Schizonepetae Herba and Saposhnikoviae Radix in treatment of ulcerative colitis]. 2019

Ying Qu, and Shu-Xin Zhang, and Lu Zhou, and Li-Yuan Fu, and Zi-Hao Liu, and Shi-Ying Li, and Ting-Ting Dai, and Xiang-Yang Yang, and Hui-Ru Ji, and Min-Ran Cao
Beijing University of Traditional Chinese Medicine Beijing 100029,China.

The aim of this paper was to screen the active targets of Schizonepetae Herba and Saposhnikoviae Radix in the treatment of ulcerative colitis by means of network pharmacology,and to investigate their mechanism of action. The effective components of Schizonepetae Herba and Saposhnikoviae Radix were screened out by traditional Chinese medicine systematic pharmacological( TCMSP)database,with oral bioavilability( OB) ≥30% and drug-like( DL) ≥18% selected as the thresholds. Target PPI network was built between the main components and their corresponding targets. One hundred and eighty-two human genes corresponding to the medicine target sites were obtained from Uniprot database; 3 874 genes corresponding to ulcerative colitis were obtained from Genecard database.A total of 115 intersection genes were screened from disease genes and medicine genes,and the PPI interaction analysis was conducted by using String tool. Disease-target PPI network was drawn by using Cytoscape software,and component-target-disease network was constructed. One hundred and eight nodes and 1 882 connections were found,and then Cytoscape software was used to merge the networks and filter the core network for gene GO function analysis and KEGG pathway enrichment analysis. The mechanism of Schizonepetae Herba and Saposhnikoviae Radix was then verified by animal experiment. Gene GO functional analysis suggested that biological process,molecular functions and cell components were involved,and it was found that ulcerative colitis might be related to transcription factor activity,and cytokine receptor binding,etc. Gene KEGG pathway enrichment analysis showed that the mechanism of ulcerative colitis might be associated with TNF and Toll-like receptors( TLRs) signaling pathway-mediated cytoinflammatory factors interleukin-1( IL-1) and interleukin-6( IL6). The possible mechanism of the effective components of Schizonepetae Herba and Saposhnikoviae Radix in treating ulcerative colitis might be related to intervening the cytokine receptor binding of TNF and TLRs signaling pathways,reducing the transcription of nuclear factor-kappaB( NF-κB),and inhibiting the secretion of intestinal inflammatory factors IL-1 and IL-6.

UI MeSH Term Description Entries
D007378 Interleukins Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli. Interleukin
D008516 Medicine, Chinese Traditional A system of traditional medicine which is based on the beliefs and practices of the Chinese culture. Chinese Medicine, Traditional,Chung I Hsueh,Traditional Medicine, Chinese,Zhong Yi Xue,Chinese Traditional Medicine,Traditional Chinese Medicine,Traditional Tongue Assessment,Traditional Tongue Diagnosis,Hsueh, Chung I,Tongue Assessment, Traditional,Tongue Diagnoses, Traditional,Tongue Diagnosis, Traditional,Traditional Tongue Assessments,Traditional Tongue Diagnoses
D008517 Phytotherapy Use of plants or herbs to treat diseases or to alleviate pain. Herb Therapy,Herbal Therapy
D003093 Colitis, Ulcerative Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN. Colitis Gravis,Idiopathic Proctocolitis,Inflammatory Bowel Disease, Ulcerative Colitis Type,Ulcerative Colitis
D004365 Drugs, Chinese Herbal Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China. Chinese Herbal Drugs,Plant Extracts, Chinese,Chinese Drugs, Plant,Chinese Plant Extracts,Extracts, Chinese Plant,Herbal Drugs, Chinese
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012984 Software Sequential operating programs and data which instruct the functioning of a digital computer. Computer Programs,Computer Software,Open Source Software,Software Engineering,Software Tools,Computer Applications Software,Computer Programs and Programming,Computer Software Applications,Application, Computer Software,Applications Software, Computer,Applications Softwares, Computer,Applications, Computer Software,Computer Applications Softwares,Computer Program,Computer Software Application,Engineering, Software,Open Source Softwares,Program, Computer,Programs, Computer,Software Application, Computer,Software Applications, Computer,Software Tool,Software, Computer,Software, Computer Applications,Software, Open Source,Softwares, Computer Applications,Softwares, Open Source,Source Software, Open,Source Softwares, Open,Tool, Software,Tools, Software
D015398 Signal Transduction The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway. Cell Signaling,Receptor-Mediated Signal Transduction,Signal Pathways,Receptor Mediated Signal Transduction,Signal Transduction Pathways,Signal Transduction Systems,Pathway, Signal,Pathway, Signal Transduction,Pathways, Signal,Pathways, Signal Transduction,Receptor-Mediated Signal Transductions,Signal Pathway,Signal Transduction Pathway,Signal Transduction System,Signal Transduction, Receptor-Mediated,Signal Transductions,Signal Transductions, Receptor-Mediated,System, Signal Transduction,Systems, Signal Transduction,Transduction, Signal,Transductions, Signal
D051193 Toll-Like Receptors A family of pattern recognition receptors characterized by an extracellular leucine-rich domain and a cytoplasmic domain that share homology with the INTERLEUKIN 1 RECEPTOR and the DROSOPHILA toll protein. Following pathogen recognition, toll-like receptors recruit and activate a variety of SIGNAL TRANSDUCING ADAPTOR PROTEINS. Receptors, Toll-Like,Toll-Like Receptor,Receptor, Toll-Like,Receptors, Toll Like,Toll Like Receptor,Toll Like Receptors

Related Publications

Ying Qu, and Shu-Xin Zhang, and Lu Zhou, and Li-Yuan Fu, and Zi-Hao Liu, and Shi-Ying Li, and Ting-Ting Dai, and Xiang-Yang Yang, and Hui-Ru Ji, and Min-Ran Cao
February 2014, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Ying Qu, and Shu-Xin Zhang, and Lu Zhou, and Li-Yuan Fu, and Zi-Hao Liu, and Shi-Ying Li, and Ting-Ting Dai, and Xiang-Yang Yang, and Hui-Ru Ji, and Min-Ran Cao
October 2021, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Ying Qu, and Shu-Xin Zhang, and Lu Zhou, and Li-Yuan Fu, and Zi-Hao Liu, and Shi-Ying Li, and Ting-Ting Dai, and Xiang-Yang Yang, and Hui-Ru Ji, and Min-Ran Cao
October 2019, Medical science monitor : international medical journal of experimental and clinical research,
Ying Qu, and Shu-Xin Zhang, and Lu Zhou, and Li-Yuan Fu, and Zi-Hao Liu, and Shi-Ying Li, and Ting-Ting Dai, and Xiang-Yang Yang, and Hui-Ru Ji, and Min-Ran Cao
May 2005, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Ying Qu, and Shu-Xin Zhang, and Lu Zhou, and Li-Yuan Fu, and Zi-Hao Liu, and Shi-Ying Li, and Ting-Ting Dai, and Xiang-Yang Yang, and Hui-Ru Ji, and Min-Ran Cao
July 2023, Journal of AOAC International,
Ying Qu, and Shu-Xin Zhang, and Lu Zhou, and Li-Yuan Fu, and Zi-Hao Liu, and Shi-Ying Li, and Ting-Ting Dai, and Xiang-Yang Yang, and Hui-Ru Ji, and Min-Ran Cao
May 2016, Zhonghua yi shi za zhi (Beijing, China : 1980),
Ying Qu, and Shu-Xin Zhang, and Lu Zhou, and Li-Yuan Fu, and Zi-Hao Liu, and Shi-Ying Li, and Ting-Ting Dai, and Xiang-Yang Yang, and Hui-Ru Ji, and Min-Ran Cao
April 2020, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Ying Qu, and Shu-Xin Zhang, and Lu Zhou, and Li-Yuan Fu, and Zi-Hao Liu, and Shi-Ying Li, and Ting-Ting Dai, and Xiang-Yang Yang, and Hui-Ru Ji, and Min-Ran Cao
June 2016, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Ying Qu, and Shu-Xin Zhang, and Lu Zhou, and Li-Yuan Fu, and Zi-Hao Liu, and Shi-Ying Li, and Ting-Ting Dai, and Xiang-Yang Yang, and Hui-Ru Ji, and Min-Ran Cao
September 2019, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Ying Qu, and Shu-Xin Zhang, and Lu Zhou, and Li-Yuan Fu, and Zi-Hao Liu, and Shi-Ying Li, and Ting-Ting Dai, and Xiang-Yang Yang, and Hui-Ru Ji, and Min-Ran Cao
October 2022, Chinese herbal medicines,
Copied contents to your clipboard!