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Ectopic Cortisol-producing Adrenocortical Adenoma Detected by 131I-6β-iodomethyl-norcholesterol Scintigraphy. 2020
Seisuke Sato, and
Hitomi Imachi, and
Toshihiro Kobayashi, and
Kensaku Fukunaga, and
Jingya Lyu, and
Tao Dong, and
Yuuki Yoshioka, and
Takanobu Saheki, and
Youko Fukata, and
Natsuki Ban, and
Kurumi Urushihara, and
Kyuuichi Kadota, and
Koji Murao
Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan.
A 50-year-old man was referred to our department for overt Cushing's syndrome (CS). His plasma cortisol concentrations were 314 μg/L, and his urinary cortisol concentrations were 431 μg/day. The plasma adrenocorticotropic hormone (ACTH) concentration was below the detectable limit. Computed tomography revealed atrophy of both adrenal glands and the presence of a left pararenal tumor. 131I-6β-iodomethyl-norcholesterol scintigraphy showed an intense uptake by the left pararenal tumor. These findings suggested that the left pararenal tumor was ectopic cortisol-producing adrenocortical adenoma. This case serves as a reminder that 131I-6β-iodomethyl-norcholesterol scintigraphy is an effective method for diagnosing ACTH-independent CS in which no adrenal tumor has been found.
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