Electrochemically generated N-iodoaminium species as key intermediates for selective methyl sulphonylimination of tertiary amines. 2020

Binbin Huang, and Chao Yang, and Jia Zhou, and Wujiong Xia
State Key Lab of Urban Water Resource and Environment, School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China. jiazhou@hit.edu.cn xiawj@hit.edu.cn.

Reported herein is a straightforward protocol for approaching N-sulphonylamidines via an electricity-driven, iodine-mediated cross dehydrogenative condensation (CDC) between sulphonamides and tertiary amines, which features exclusive N-CH3 selectivity for the amine partners. Mechanistic studies indicate that an in situ generated N-iodoaminium species serves as the key intermediate.

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