BIOMAT Database Logo BIOMAT Database Logo

Comparative bioavailability of oral dosage forms of oxazepam--correlation with in vitro dissolution rate. 1977

A Pilbrant, and P O Glenne, and A Sundwall, and J Vessman, and M Wretlind

Four oxazepam tablet preparations and a suspension of micronized oxazepam in water were given to healthy, fasting volunteers in a comparative bioavailability study using a partial cross-over design. Urinary recovery (0-72 hours) was used as a measure of extent of absorption. Peak serum concentration was used as a measure of rate of absorption. The three dosage forms having the highest dissolution rate in vitro were absorbed to the same extent, while slower dissolving tablets were not as fully absorbed. Peak serum concentration correlated linearly with in vitro dissolution rate. Single oral doses of oxazepam tablets containing 10, 15 and 25 mg showed equal rates and extents of absorption and produced serum concentrations linearly correlated with dose.

UI MeSH Term Description Entries
D008297 Male Males
D010076 Oxazepam A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia. Adumbran,Serax,Tazepam
D002986 Clinical Trials as Topic Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries. Clinical Trial as Topic
D004341 Drug Evaluation Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals. Evaluation Studies, Drug,Drug Evaluation Studies,Drug Evaluation Study,Drug Evaluations,Evaluation Study, Drug,Evaluation, Drug,Evaluations, Drug,Studies, Drug Evaluation,Study, Drug Evaluation
D005260 Female Females
D006207 Half-Life The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity. Halflife,Half Life,Half-Lifes,Halflifes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D001682 Biological Availability The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action. Availability Equivalency,Bioavailability,Physiologic Availability,Availability, Biologic,Availability, Biological,Availability, Physiologic,Biologic Availability,Availabilities, Biologic,Availabilities, Biological,Availabilities, Physiologic,Availability Equivalencies,Bioavailabilities,Biologic Availabilities,Biological Availabilities,Equivalencies, Availability,Equivalency, Availability,Physiologic Availabilities
D013535 Suspensions Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions. Suspension

Related Publications

A Pilbrant, and P O Glenne, and A Sundwall, and J Vessman, and M Wretlind
In vitro-in vivo correlation and dissolution studies with oral theophylline dosage forms.
February 1985, Journal of pharmaceutical sciences,
A Pilbrant, and P O Glenne, and A Sundwall, and J Vessman, and M Wretlind
"In vitro" dissolution tests for solid oral dosage forms.
September 1977, Bollettino chimico farmaceutico,
A Pilbrant, and P O Glenne, and A Sundwall, and J Vessman, and M Wretlind
Comparative bioavailability of two oral dosage forms of oxtriphylline.
February 1977, Current therapeutic research, clinical and experimental,
A Pilbrant, and P O Glenne, and A Sundwall, and J Vessman, and M Wretlind
Dissolution of theophylline from sustained-release dosage forms and correlation with saliva bioavailability parameters.
October 1987, Journal of pharmaceutical sciences,
A Pilbrant, and P O Glenne, and A Sundwall, and J Vessman, and M Wretlind
A comparative bioavailability of 2 oral solid phenytoin dosage forms.
April 1989, The Central African journal of medicine,
A Pilbrant, and P O Glenne, and A Sundwall, and J Vessman, and M Wretlind
Agglomerated oral dosage forms of artemisinin/β-cyclodextrin spray-dried primary microparticles showing increased dissolution rate and bioavailability.
September 2013, AAPS PharmSciTech,
A Pilbrant, and P O Glenne, and A Sundwall, and J Vessman, and M Wretlind
Bioavailability of valsartan oral dosage forms.
March 2014, Clinical pharmacology in drug development,
A Pilbrant, and P O Glenne, and A Sundwall, and J Vessman, and M Wretlind
Dissolution rate limited bioavailability of flutamide, and in vitro - in vivo correlation.
January 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V,
A Pilbrant, and P O Glenne, and A Sundwall, and J Vessman, and M Wretlind
In vitro dissolution rates of aminorex dosage forms and their correlation with in vivo availability.
December 1969, Journal of pharmaceutical sciences,
A Pilbrant, and P O Glenne, and A Sundwall, and J Vessman, and M Wretlind
Dissolution testing of oral modified-release dosage forms.
July 2012, The Journal of pharmacy and pharmacology,
Copied contents to your clipboard!