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Effect of the nanocapsulated adjuvant Sapomax on the expression of some immune response genes. 2020
Aizhan S Turmagambetova, and
Madina S Alexyuk, and
Andrey P Bogoyavlenskiy, and
Pavel G Alexyuk, and
Irina A Zaitseva, and
Elmira S Omirtaeva, and
Nadezhda S Sokolova, and
Vladimir E Berezin
Research and Production Center for Microbiology and Virology, 105, Bogenbai Batyr Street, 050010, Almaty, Kazakhstan. aichyck@mail.ru.
The use of the nanocapsulated adjuvant Sapomax increased the expression of innate immunity genes (H2Q10, Ddx58, Tyk2, Tlr3, Tlr7, and TNF) responsible for the primary recognition of influenza virus, i.e., those belonging to the RLR and TLR families; genes involved in stimulating the production of type I and III IFN and pro-inflammatory cytokines; and Th1 and Th2 cellular immunity genes (Ccr4, Ccr5, IFNγ, IL-2, IL-4, and IL-10) responsible for triggering regulatory immune mechanisms in the cell. The high immunological activity of the plant-derived nanocapsulated adjuvant Sapomax may be used to enhance the efficacy of vaccines.
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