The Big Five and the interpersonal circumplex are among the most extensively used structural frameworks in personality research. Of the five factors, extraversion and agreeableness are theorized to carry the most interpersonal context, however, all five factors are likely to have important interpersonal implications. In the present study, we evaluated the associations between domains of interpersonal functioning and the Big Five domains and facets using the bootstrapped structural summary method. Results suggested that all Big Five traits showed prototypical and specific interpersonal profiles, with variability observed across lower order facets and domains of interpersonal functioning. Several Big Five traits and facets not overtly related to interpersonal behavior nonetheless showed specific, prototypical associations to interpersonal profiles. Findings suggest that Big Five traits and facets are saturated with interpersonal content and even personality characteristics that are not explicitly interpersonal may still have specific interpersonal implications.