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The milk-ejecting response of lactating mouse mammary gland tissue to ovine pineal extracts indicated the presence of a neurohormone-like bioactivity in this tissue. After successive fractionation on gel permeation chromatography and reversed-phase liquid chromatography (HPLC) in conjunction with radioimmunoassays (RIA), it was demonstrated that the milk-ejection response to ovine pineal components with an Mr less than 1,000 corresponded to a biologically active peptide sequence that probably differs from that of arginine vasopressin, arginine vasotocin, and oxytocin and from peptides with a COOH-terminal Pro-Arg-Gly-amide ending. Gel permeation chromatography in formic acid appeared also to indicate the presence of a noncovalent interaction of the neurohormone-like bioactivity with proteins (Mr greater than 25,000) of the pineal.
H P Noteborn, and
I Ebels, and
A C Reinharz, and
P Pévet, and
B Benson, and
C A Salemink
July 1980,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
H P Noteborn, and
I Ebels, and
A C Reinharz, and
P Pévet, and
B Benson, and
C A Salemink
September 1992,
Journal of pineal research,
H P Noteborn, and
I Ebels, and
A C Reinharz, and
P Pévet, and
B Benson, and
C A Salemink
January 1977,
Neuroendocrinology,
H P Noteborn, and
I Ebels, and
A C Reinharz, and
P Pévet, and
B Benson, and
C A Salemink
December 1981,
The Journal of endocrinology,
H P Noteborn, and
I Ebels, and
A C Reinharz, and
P Pévet, and
B Benson, and
C A Salemink
December 1967,
The Journal of clinical endocrinology and metabolism,
H P Noteborn, and
I Ebels, and
A C Reinharz, and
P Pévet, and
B Benson, and
C A Salemink
January 1980,
Biochemistry,
H P Noteborn, and
I Ebels, and
A C Reinharz, and
P Pévet, and
B Benson, and
C A Salemink
September 1995,
Experientia,
H P Noteborn, and
I Ebels, and
A C Reinharz, and
P Pévet, and
B Benson, and
C A Salemink
July 1976,
The British journal of radiology,
H P Noteborn, and
I Ebels, and
A C Reinharz, and
P Pévet, and
B Benson, and
C A Salemink
January 1958,
Il Farmaco; edizione scientifica,
H P Noteborn, and
I Ebels, and
A C Reinharz, and
P Pévet, and
B Benson, and
C A Salemink
January 1982,
Progress in clinical and biological research,
