Biomaterial Database

[Dysplastic melanocytic nevi: quantitative ultrastructural investigation comparing intraepidermal melanocytes of dysplastic melanocytic nevi, superficial spreading melanoma, nevocellular nevi, and normal skin]. 1988

Y Seki, and T B Fitzpatrick, and A R Rhodes

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008544	Melanocytes	Mammalian pigment cells that produce MELANINS, pigments found mainly in the EPIDERMIS, but also in the eyes and the hair, by a process called melanogenesis. Coloration can be altered by the number of melanocytes or the amount of pigment produced and stored in the organelles called MELANOSOMES. The large non-mammalian melanin-containing cells are called MELANOPHORES.	Melanocyte
D008545	Melanoma	A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	Malignant Melanoma,Malignant Melanomas,Melanoma, Malignant,Melanomas,Melanomas, Malignant
D008854	Microscopy, Electron	Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.	Electron Microscopy
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009506	Nevus	A circumscribed stable malformation of the skin and occasionally of the oral mucosa, which is not due to external causes and therefore presumed to be of hereditary origin.	Mole, Skin,Moles, Skin,Skin Mole,Nevi,Skin Moles
D004416	Dysplastic Nevus Syndrome	Clinically atypical nevi (usually exceeding 5 mm in diameter and having variable pigmentation and ill defined borders) with an increased risk for development of non-familial cutaneous malignant melanoma. Biopsies show melanocytic dysplasia. Nevi are clinically and histologically identical to the precursor lesions for melanoma in the B-K mole syndrome. (Stedman, 25th ed)	B-K Mole Syndrome,Familial Atypical Multiple Mole-Melanoma,Nevus Syndrome, Dysplastic,Nevus, Dysplastic,Dysplastic Nevi,B K Mole Syndrome,Dysplastic Nevus,Familial Atypical Multiple Mole Melanoma,Nevi, Dysplastic,Syndrome, B-K Mole,Syndrome, Dysplastic Nevus
D004817	Epidermis	The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Y Seki, and T B Fitzpatrick, and A R Rhodes

Increased intraepidermal melanocyte frequency and size in dysplastic melanocytic nevi and cutaneous melanoma. A comparative quantitative study of dysplastic melanocytic nevi, superficial spreading melanoma, nevocellular nevi, and solar lentigines.

May 1983, The Journal of investigative dermatology,

Y Seki, and T B Fitzpatrick, and A R Rhodes

Dysplastic nevi in relation to superficial spreading melanoma.

January 1993, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,

Y Seki, and T B Fitzpatrick, and A R Rhodes

Dysplastic melanocytic nevi. Normal variants or melanoma precursors?

April 1990, Archives of dermatology,

Y Seki, and T B Fitzpatrick, and A R Rhodes

Dysplastic melanocytic nevi contain high levels of pheomelanin: quantitative comparison of pheomelanin/eumelanin levels between normal skin, common nevi, and dysplastic nevi.

October 1991, Pigment cell research,

Y Seki, and T B Fitzpatrick, and A R Rhodes

Monoclonal antibody (AFH1) immunoreactive on morphologically abnormal basal melanocytes within dysplastic nevi, nevocellular nevus nests, and melanoma.

April 1988, The Journal of investigative dermatology,

Y Seki, and T B Fitzpatrick, and A R Rhodes

In vivo optical properties of melanocytic skin lesions: common nevi, dysplastic nevi and malignant melanoma.

January 2010, Photochemistry and photobiology,