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Female guinea pigs were given daily doses of a combination of oral contraceptive (OC) agents, consisting of mestranol and norethynodrel suspended in sesame oil or distilled H2O, and were infected in the genital tract with the chlamydial agent of guinea pig inclusion conjunctivitis (GPIC). Counts of chlamydial inclusions in cells of vaginal smears collected during infection, showed prolongation and enhancement of infection in OC-treated animals as compared with controls. Appearance of IgG and IgA antibodies to GPIC in genital secretions, as determined by enzyme-linked immunosorbent assay (ELISA), was also delayed in OC-treated animals as compared with controls. OC-treated infected animals were killed on days 15 and 43, and gross pathological evidence for ascending infection culminating in salpingitis was found in all of five and four of five animals, respectively. On the other hand, among untreated infected controls on each sacrifice day, only one of five animals had any evidence for ascending infection. Chlamydiae were detected by light and electron microscopy in fallopian tube tissue collected on day 15 following OC-treatment but not in tissue from control animals.
A L Barron, and
J N Pasley, and
R G Rank, and
H J White, and
R E Mrak
December 1980,
American journal of obstetrics and gynecology,
A L Barron, and
J N Pasley, and
R G Rank, and
H J White, and
R E Mrak
January 1994,
Sexually transmitted diseases,
A L Barron, and
J N Pasley, and
R G Rank, and
H J White, and
R E Mrak
January 1982,
Scandinavian journal of infectious diseases. Supplementum,
A L Barron, and
J N Pasley, and
R G Rank, and
H J White, and
R E Mrak
April 1983,
British medical bulletin,
A L Barron, and
J N Pasley, and
R G Rank, and
H J White, and
R E Mrak
November 1979,
Infection and immunity,
A L Barron, and
J N Pasley, and
R G Rank, and
H J White, and
R E Mrak
April 1985,
Infection and immunity,
A L Barron, and
J N Pasley, and
R G Rank, and
H J White, and
R E Mrak
November 1982,
Fertility and sterility,
A L Barron, and
J N Pasley, and
R G Rank, and
H J White, and
R E Mrak
April 1980,
Lancet (London, England),
A L Barron, and
J N Pasley, and
R G Rank, and
H J White, and
R E Mrak
April 1985,
Surgery, gynecology & obstetrics,
A L Barron, and
J N Pasley, and
R G Rank, and
H J White, and
R E Mrak
January 1990,
JAMA,
