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Eight mongrel dogs received a standard daily i.v. infusion of 20 mg/kg b.w. deaggregated horse-anti-dog-lymphocyte-globulin (ALG) and additional prednisolone (1 mg/kg b.w. daily i.v.) over a maximum period of 82 days following pretreatment with deaggregated normal horse IgG. No sensitization against horse protein was observed during therapy of afterwards as proved by lack of humoral antibodies against horse antigens, maintained lymphopenia, good compatibility, longterm prolongation of xenogeneic skin graft survival (85.6+/-20.6 days, n=8' untreated controls 12.5+/-1.3 days, n=4) and longterm suppression of cytotoxic antibodies against donor lymphocytes. The level of preformed agglutinating antibodies against horse erythrocytes was significantly reduced, while preformed antibodies against other species remained normal. The immune response to a challenge injection of anti-lymphocyte-serum (ALS) 6-11 weeks after termination of treatment was significantly lower in the ALG treated animals as compared to the control group. These results suggest the involvement of a specific mechanism of unresponsiveness against ALG other than immunosuppression only. It is concluded, that by the described method sensitization against ALG can be prevented during longterm treatment.
J Scheel, and
K H Duswald, and
J Ring, and
J Seifert, and
S Scholz, and
W Brendel
January 1971,
Polish medical journal,
J Scheel, and
K H Duswald, and
J Ring, and
J Seifert, and
S Scholz, and
W Brendel
January 1981,
Archivum immunologiae et therapiae experimentalis,
J Scheel, and
K H Duswald, and
J Ring, and
J Seifert, and
S Scholz, and
W Brendel
January 1970,
Progress in immunobiological standardization,
J Scheel, and
K H Duswald, and
J Ring, and
J Seifert, and
S Scholz, and
W Brendel
April 1969,
Annals of surgery,
J Scheel, and
K H Duswald, and
J Ring, and
J Seifert, and
S Scholz, and
W Brendel
January 1971,
International archives of allergy and applied immunology,
J Scheel, and
K H Duswald, and
J Ring, and
J Seifert, and
S Scholz, and
W Brendel
January 1983,
Transfusion,
J Scheel, and
K H Duswald, and
J Ring, and
J Seifert, and
S Scholz, and
W Brendel
July 1999,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
J Scheel, and
K H Duswald, and
J Ring, and
J Seifert, and
S Scholz, and
W Brendel
January 1973,
Acta medica Polona,
J Scheel, and
K H Duswald, and
J Ring, and
J Seifert, and
S Scholz, and
W Brendel
February 1970,
Clinical and experimental immunology,
J Scheel, and
K H Duswald, and
J Ring, and
J Seifert, and
S Scholz, and
W Brendel
July 1976,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
